Abstract
The inter- and intramolecular addition of nitrogen pronucleophiles to methylenecyclopropanes proceeds smoothly in the presence of palladium catalyst, giving the corresponding hydroamination products in good to excellent yields. The reaction proceeds mainly through cleavage of a distal bond of methylenecyclopropanes.
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Nakamura, I., Itagaki, H. & Yamamoto, Y. Palladium-catalyzed Inter- and Intramolecular Hydroamination of Methylenecyclopropanes with Amines. Chemistry of Heterocyclic Compounds 37, 1532–1540 (2001). https://doi.org/10.1023/A:1014513411239
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DOI: https://doi.org/10.1023/A:1014513411239