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Sequence and Phylogenetic Analysis of Hepatitis B Virus Genotype G Isolated in Germany

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Abstract

Genotype G of hepatitis B virus (HBV) has only recently been discovered. This report describes the full-length sequence of genotype G HBV (designated 235/01) isolated in Germany from a chronic HBV carrier. The patient was hepatitis B e antigen-positive, had high HBV DNA levels of about 1010 copies/ml serum, lacked a measurable anti-HBc response, and was coinfected with human immunodeficiency virus type 1. Genome 235/01 showed characteristic genotype G-specific features: stop codons at codon 2 and 28 of the pre-C region and insertion of 36 nucleotides at the 5′ end of the C gene. It was nearly identical (≥99.7% identity) to both genotype G genomes (B1-89 and FR1 from France) described so far, suggesting either close epidemiological link among European genotype G isolates or high genetic stability of genotype G.

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Authors and Affiliations

  1. Department of Virology, Bernhard-Nocht-Institute for Tropical Medicine, 20359, Hamburg, Germany

    Simon Vieth, Christian Drosten & Thomas Nippraschk

  2. Clinical Department, Bernhard-Nocht-Institute for Tropical Medicine, 20359, Hamburg, Germany

    Christoph Manegold

  3. Department of Virology, Bernhard-Nocht-Institute for Tropical Medicine, Bernhard-Nocht-Strasse 74, D-20359, Hamburg, Federal Republic of Germany

    Stephan Günther

Authors
  1. Simon Vieth
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  2. Christoph Manegold
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  3. Christian Drosten
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  4. Thomas Nippraschk
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  5. Stephan Günther
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Vieth, S., Manegold, C., Drosten, C. et al. Sequence and Phylogenetic Analysis of Hepatitis B Virus Genotype G Isolated in Germany. Virus Genes 24, 153–156 (2002). https://doi.org/10.1023/A:1014572600432

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