Abstract
Hydroxyapatite (HAP) particles having spherical geometry and 125–1000 μm in size range were prepared using a solid-in-water-in-oil (S/W/O) emulsion, cross-linking technique. An aqueous solution of chitosan containing different loading of HAP was dispersed as droplet in liquid paraffin using a stabilizing agent. Cross-linking of chitosan was induced by adding appropriate amount of glutaraldehyde saturated toluene. Chitosan microspheres containing HAP were sintered at 1150 °C to obtain pure HAP microspheres. The spheres thus produced were examined by scanning electron microscopy. The percentage yield and size distributions of the spheres were also determined.
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Sunny, M.C., Ramesh, P. & Varma, H.K. Microstructured microspheres of hydroxyapatite bioceramic. Journal of Materials Science: Materials in Medicine 13, 623–632 (2002). https://doi.org/10.1023/A:1015709705074
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DOI: https://doi.org/10.1023/A:1015709705074