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Adhesion-Mediated Signaling in the Regulation of Mammary Epithelial Cell Survival

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Abstract

Tissue architecture in multicellular organismsis maintained through adhesive interactions betweencells and their neighbors, and between cells and theunderlying extracellular matrix. These interactions are important in the dynamic regulation oftissue organization as well as the control of cellproliferation, differentiation and apoptosis. Theultimate goal of this regulation is to promote cellgrowth and differentiation only when the cell is inthe correct location, and to delete cells that havebecome displaced from their proper environment. Ittherefore plays an important role in development andtissue remodeling. In this review we consider themolecular mechanisms by which cell-matrix interactionscontribute to cell survival, and discuss their role inmammary gland development and function.

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  1. Charles H. Streuli
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  2. Andrew P. Gilmore
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Streuli, C.H., Gilmore, A.P. Adhesion-Mediated Signaling in the Regulation of Mammary Epithelial Cell Survival. J Mammary Gland Biol Neoplasia 4, 183–191 (1999). https://doi.org/10.1023/A:1018729308878

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