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The Effect of Aluminum Hydroxide Dissolution on the Bleeding of Aluminum Lake Dyes

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Abstract

The effect of pH on the bleeding of FD&C yellow No. 5 aluminum lake and FD&C red No. 40 aluminum lake was investigated. The pH–bleeding profiles corresponded to the pH–solubility profile of aluminum hydroxide. The similarity of the bleeding profiles of both lake dyes and the pH–solubility profile of aluminum hydroxide indicates that pH related bleeding, other than that occurring by competition with anions, is a result of dissolution of the aluminum hydroxide substrate. This dissolution is related to the properties of the substrate rather than to the structure of adsorbed dye.

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Author notes

  1. Archana Desai

    Present address: Receptor Laboratories, 2201 West Campbell Drive, Chicago, Illinois, 60612

Authors and Affiliations

  1. Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, Indiana, 47907

    Archana Desai, Garnet E. Peck & Stanley L. Hem

  2. School of Civil Engineering, Purdue University, West Lafayette, Indiana, 47907

    Janet E. Lovell

  3. Department of Agronomy, Purdue University, West Lafayette, Indiana, 47907

    Joe L. White

Authors
  1. Archana Desai
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  2. Garnet E. Peck
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  3. Janet E. Lovell
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  4. Joe L. White
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  5. Stanley L. Hem
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Desai, A., Peck, G.E., Lovell, J.E. et al. The Effect of Aluminum Hydroxide Dissolution on the Bleeding of Aluminum Lake Dyes. Pharm Res 10, 1458–1460 (1993). https://doi.org/10.1023/A:1018971208521

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  • DOI: https://doi.org/10.1023/A:1018971208521

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