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The Influence of Thermal Treatment on the Physical-Mechanical and Dissolution Properties of Tablets Containing Poly(DL-Lactic Acid)

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Abstract

Five molecular weight grades of poly(DL-lactic acid) (PLA) were incorporated as organic and aqueous pseudolatex binders into matrix tablet formulations containing microcrystalline cellulose and the model drug theophylline. The tablets were thermally treated to temperatures above and below the glass transition temperature (T g) of the PLA. The results of the dissolution studies showed that thermally treating the tablets to temperatures above the T g of the PLA significantly retarded the matrix drug release compared to tablets which were not thermally treated. The retardation in drug release could be attributed to a stronger compact and a more efficient redistribution of polymer throughout the tablet matrix, based on fundamental principles of annealing. In addition, results from tablet index testing supported the dissolution results. The bonding index of the compact formulations increased after thermal treatment above the T g of the PLA. Gel permeation chromatography and differential scanning calorimetry studies demonstrated that thermal treatment had no significant effect on the molecular weight and the glass transition temperature of (PLA) alone and in combination with other components of the tablet formulation.

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REFERENCES

  1. L. Nielson. Mechanical Properties of Polymers and Composites, Marcel Dekker, New York, 1974, pp. 139–229.

    Google Scholar 

  2. Encyclopedia of Polymer Science and Engineering, Vol. 2. Anionic Polymerization and Cationic Polymerization, John Wiley and Sons, New York, 1985, pp. 43–53.

  3. S. Porter. The use of Opadry, Coateric and Surelease in the aqueous film coating of pharmaceutical oral dosage forms. In J. W. McGinity (ed.), Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms, Marcel Dekker, New York, 1989, pp. 317–362.

    Google Scholar 

  4. M. R. Harris, I. Ghebre-Sellassie, and R. U. Nesbitt. A water-based coating process for sustained release. Pharm. Tech. 10(9):102–107 (1986).

    Google Scholar 

  5. T. Wheatly. Applications of Aquacoat ethylcellulose aqueous disperions for sustained release. In Y. Kaweshima (ed.), Recent Advances on Aqueous Polymeric Coating System and Related Techniques, Proceedings of the Pre World Congress, Particle Technology, Gifu, Japan, Sept. 1990, pp. 11–17.

  6. B. H. Lippold, B. K. Sutter, and B. C. Lippold. Parameters controlling drug release from pellets coated with aqueous ethyl cellulose dispersions. Int. J. Pharm. 54:15–25 (1989).

    Google Scholar 

  7. I. Ghebre-Sellassie, U. Iyer, D. Kubert, and M. B. Fawzi. Characterization of a new water-based coating for modified-release preparations. Pharm. Tech. 12(9):96–106 (1988).

    Google Scholar 

  8. E. S. Ghali, G. H. Klinger, and J. B. Schwartz. Thermal treatment of beads with wax for controlled release. Drug Dev. Ind. Pharm. 15:1311–1328 (1989).

    Google Scholar 

  9. M. O. Omelczuk and J. W. McGinity. The influence of polymer glass transition temperature and molecular weight on the drug release from tablets containing poly(DL-lactic acid). Pharm. Res. 9:26–32 (1992).

    Google Scholar 

  10. M. O. Omelczuk. An Investigation of the Chemical, Physical-Mechanical, and Dissolution Properties of Controlled Release Tablets Containing Poly(d,l-lactic acid), Ph.D. dissertation, University of Texas at Austin, Austin, 1991.

  11. M. Coffin and J. W. McGinity. Biodegradable pseudolatexes: The chemical stability of poly(DL-lactide) and poly(ecaprolactone) nanoparticles in aqueous media. Pharm Res. 9:200–205 (1992).

    Google Scholar 

  12. M. Coffin. The Development and Physical-Chemical Properties of Biodegradable Pseudolatexes and Their Application to Sustained Release Drug Delivery Systems, Ph.D. dissertation, University of Texas at Austin, Austin, 1990.

  13. E. N. Hiestand, J. E. Wells, C. B. Poet, and J. F. Ochs. Physical process of tableting. J. Pharm. Sci. 66:510–519 (1977).

    Google Scholar 

  14. E. N. Hiestand and D. P. Smith. Indices of tableting performance. Powder Technol. 38:145 (1984).

    Google Scholar 

  15. E. N. Hiestand. The basis for practical applications of the tableting indices. Pharm. Tech. 13(9):54–66 (1989).

    Google Scholar 

  16. R. O. Williams III and J. W. McGinity. The use of tableting indices to study the compaction properties of powders. Drug Dev. Ind. Pharm. 14:1823–1844 (1988).

    Google Scholar 

  17. M. D. Schulze and J. W. McGinity. Physical-mechanical properties of spray-dried and milled acrylic resin polymers in combination with a brittle or plastic drug. S.T.P. Pharma Sci. 1:165–171 (1991).

    Google Scholar 

  18. R. O. Williams III and J. W. McGinity. Compaction properties of microcrystalline cellulose and sodium sulfathiazole in combination with talc or magnesium stearate. J. Pharm. Sci. 78:1025–1034 (1989).

    Google Scholar 

  19. U. W. Gedde. Thermal analysis of polymers. Drug Dev. Ind. Pharm. 16:2456–2465 (1990).

    Google Scholar 

  20. H. Mark and S. Atlas. Introduction to polymer science. In H. Kaufman and J. Falcetta (eds.), Introduction to Polymer Science and Technology, John Wiley and Sons, New York, 1977, pp. 1–23.

    Google Scholar 

  21. F. W. Billmeyer. The size and weight of polymer molecules. In H. Kaufman and J. Falcetta (eds.), Introduction to Polymer Science and Technology, John Wiley and Sons, New York, 1977, pp. 154–203.

    Google Scholar 

  22. F. W. Billmeyer. Measurement of molecular weight and size. In F. Billmeyer (ed.), Textbook of Polymer Science, Wiley Interscience, New York, 1984, pp. 186–219.

    Google Scholar 

  23. M. J. Richardson. Thermal analysis of polymers using quantitative differential scanning calorimetry. Polym. Test. 4:101–115 (1984).

    Google Scholar 

  24. F. Billmeyer. Analysis and testing of polymers. In H. Kaufman and J. Falcetta (eds.), Introduction to Polymer Science and Technology, John Wiley and Sons, New York, 1977, pp. 245–252.

    Google Scholar 

  25. T. Higuchi. Mechanism of sustained-action medication. J. Pharm. Sci. 52:1145 (1963).

    Google Scholar 

  26. M. C. Gupta and V. C. Deshmukh. Thermal oxididative degradation of poly-lactic acid. I. Activation energy of thermal degradation in air. Coll. Polym. Sci. 260:308–311 (1982).

    Google Scholar 

  27. C. Stuernagel. Latex emulsification for controlled drug delivery. In J. W. McGinity (ed.), Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms, Marcel Dekker, New York, 1989, pp. 1–61.

    Google Scholar 

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Authors and Affiliations

  1. Sandoz Research Institute, Sandoz Pharmaceuticals, East Hanover, New Jersey, 07936

    Marcelo O. Omelczuk

  2. Drug Dynamics Institute, College of Pharmacy, The University of Texas at Austin, Austin, Texas, 78712

    James W. McGinity

Authors
  1. Marcelo O. Omelczuk
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  2. James W. McGinity
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Omelczuk, M.O., McGinity, J.W. The Influence of Thermal Treatment on the Physical-Mechanical and Dissolution Properties of Tablets Containing Poly(DL-Lactic Acid). Pharm Res 10, 542–548 (1993). https://doi.org/10.1023/A:1018993818206

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