Abstract
Data are summarized on the synthesis of hydroxyapatite (HA) by wet-chemical processes, solid-state reactions, and hydrothermal treatment. The conditions for HA preparation via precipitation from solutions of calcium chloride, dibasic ammonium phosphate, and aqueous ammonia are discussed at length. Detailed analysis of the fabrication and properties of calcium-phosphate-based ceramics is presented. The techniques for producing dense and porous HA ceramics are considered. The fabrication and medical applications of HA granules are discussed. Data are presented on HA-based composites.
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REFERENCES
Aoki, H., Science and Medical Applications of Hydroxyapatite, Tokyo: JAAS, 1991.
Williams, D.F., Science and Applications of Biomaterials, Adv. Mater. Technol. Monitor., 1994, no. 2, pp. 1–38.
Orlovskii, V.P., Sukhanova, G.E., Ezhova, Zh.A., and Rodicheva, G.V., Hydroxyapatite Bioceramics, Zh.Vses. Khim. O–va. im. D.I. Mendeleeva, 1991, vol. 36, no. 6, pp. 683–688.
Hench, L.L., Bioceramics and the Future, Ceramics and Society, Vincenzini, P., Ed., Faenza: Techna, 1995, pp. 101–120.
Tret'yakov, Yu.D. and Brylev, O.A., New Generation of Inorganic Functional Materials, Ross. Khim. Zh., 2000, vol. 7, no. 4, pp. 10–16.
Doremus, R.H., Review Bioceramics, J. Mater. Sci., 1992, vol. 27, no. 3, pp. 285–296.
Cao, W. and Hench, L.L., Bioactive Materials, J. Ceram. Int., 1996, vol. 22, no. 6, pp. 493–507.
Sarkisov, P.D., Mikhailenko, N.Yu., Batrak, I.K., et al., Calcium Phosphate Glass-Ceramic Coatings for Titanium Implants, in Problemy implantologii v otorinolaringologii (Implants in Otorhinolaryngology), Moscow: Press-Solo, 2000, p. 18.
Sarkisov, P.D., Michailenko, N.Yu., Stroganova, E.E., et al., Glass-Based Bioactive Calcium Phosphate Materials, Proc. XIX Int. Congress on Glass, Edinburg, 2001, p. 23.
Suchanek, W. and Yoshimura, M., Processing and Properties of HA-Based Biomaterials for Use as Hard Tissue Replacement Implants, J. Mater. Res. Soc., 1998, vol. 13, no. 1, pp. 94–103.
Hing, K.A., Best, S.M., Tanner, K.A., et al., Quantification of Bone Ingrowth within Bone Derived Porous Hydroxyapatite Implants of Varying Density, J. Mater.Sci.: Mater. Med., 1999, vol. 10, no. 10/11, pp. 633–670.
Krajewski, A., Ravaglioli, A., Roncari, E., et al., Porous Ceramic Bodies for Drug, J. Mater. Sci.: Mater. Med., 2000, vol. 11, no. 12, pp. 763–772.
Paul, W. and Sharma, C.P., Development of Porous Spherical Hydroxyapatite Granules: Application towards Protein Delivery, J. Mater. Sci.: Mater. Med., 1999, vol. 10, no. 7, pp. 383–388.
Vaz, L., Lopes, A.B., and Almeida, M., Porosity Control of Hydroxyapatite Implants, J. Mater. Sci.: Mater. Med., 1999, vol. 10, no. 10/11, pp. 239–242.
Lio, D., Fabrication of Hydroxyapatite Ceramic with Controlled Porosity, J. Mater. Sci.: Mater. Med., 1997, vol. 8, no. 8, pp. 227–232.
Itokazu, M., Esaki, M., Yamamoto, K., et al., Local Drug Delivery System Using Ceramics: Vacuum Method for Impregnating a Chemotherapeutic Agent into a Porous Hydroxyapatite Block, J. Mater. Sci.: Mater. Med., 1999, vol. 10, no. 4, pp. 249–252.
Lu, J.X., Flautre, B., and Anselme, K., Role of Interconnections in Porous Bioceramics on Bone Recolonization In Vitro and In Vivo, J. Mater. Sci.: Mater. Med., 1999, vol. 10, no. 2, pp. 111–120.
Yamamoto, M., Tabata, Y., Kawasaki, H., and Ikada, Y., Promotion of Fibrovascular Tissue Ingrowth into Porous Sponges by Basic Fibroblast Growth Factor, J.Mater. Sci.: Mater. Med., 2000, vol. 11, no. 14, pp. 213–218.
Weinlander, M., Plenk, H., Jr., Adar, F., and Holmes, R., Bioceramics and the Human Body, Ravaglioli, A. and Krajewski, A., Eds., London: Elsevier, 1992, p. 317.
Samusev, R.P. and Selin, Yu.M., Anatomiya cheloveka (Human Anatomy), Moscow: Meditsina, 1990.
Martin, R.B., Bone as a Ceramic Composite Material, Mater. Sci. Forum, 1999, vol. 7, no. 1, pp. 5–16.
Gunderson, S.L. and Schiavone, R.C., International Encyclopedia of Composites, Lee, S.M., Ed., New York: VCH, 1991, vol. 5.
Katz, J.L., The Mechanical Properties of Biological Materials, Cambridge: Cambridge Univ. Press, 1980.
Barinov, S.M. and Shevchenko, V.Ya., Prochnost' tekhnicheskoi keramiki (Strength of Technical Ceramics), Moscow: Nauka, 1997.
Shevchenko, V.Ya. and Barinov, S.M., Tekhnicheskaya keramika (Technical Ceramics), Moscow: Nauka, 1993.
Buravov, A.D., Barinov, S.M., Grigorjev, O.N., et al., Carbon-and Ceramic-Matrix Composites, London: Chapman and Hall, 1995, p. 380.
Monma, H.J., Processing of Synthetic Hydroxyapatite, J. Ceram. Soc. Jpn., Dent. Res., 1980, vol. 8, no. 40, pp. 97–102.
Slosarczyk, A., Stobierska, E., Paszkiewicz, Z., and Gawlicki, M., Calcium Phosphate Materials Prepared from Precipitates with Various Calcium: Phosphorus Molar Ratios, J. Am. Ceram. Soc., 1996, vol. 79, no. 10, pp. 2539–2544.
Mortier, A., Lemaitre, J., Rondrique, L., et al., Synthesis and Thermal Behavior of Well Crystallized Calcium-Deficient Phosphate Apatite, J. Solid State Chem., 1989, vol. 26, no. 2, pp. 215–219.
Barinov, S.M. and Komlev, V.S., Hydroxyapatite-Base Granules for Targeted and Time-Controlled Drug Delivery, Book of Lectures Presented at the 3rd Course on Biomaterials, Rustichelli, F. and Davidson, C., Eds., Ancona, 2001, pp. 1–7.
Klyuchnikov, N.G., Rukovodstvo po neorganicheskomu sintezu (A Guide to Inorganic Synthesis), Moscow: Khimiya, 1965.
Kibal'chits, V. and Komarov, V.F., High-Speed Synthesis of Hydroxyapatite Crystals, Zh. Neorg. Khim., 1980, vol. 25, no. 2, pp. 565–567.
Orlovskii, V.P. and Barinov, S.M., Hydroxyapatite and Hydroxyapatite-Matrix Ceramics: A Survey, Russ. J.Inorg. Chem., 2001, vol. 46, no. 2, pp. 129–149.
Aizawa, M., Hanazawa, T., Itatani, K., et al., Characterization of Hydroxyapatite Powders Prepared by Ultrasonic Spray-Pyrolysis Technique, J. Mater. Sci., 1999, vol. 34, no. 12, p. 2865.
Kokubo, T., Potential of Ceramics as Biomaterials, Ceramics and Society, Brook, R.J., Ed., Faenza: Techna, 1995.
Orlovskii, V.P., Ezhova, Zh.A., Rodicheva, G.V., et al., Hydroxyapatite Phase Relations in the System CaCl2–(NH4)2HPO4–NH4OH–H2O (25°C), Zh. Neorg. Khim., 1992, vol. 37, no. 4, pp. 881–883.
Orlovskii, V.P., Ezhova, Zh.A., Rodicheva, G.V., et al., Structural Transformations of Hydroxyapatite in the Range 100–1600°C, Zh. Neorg. Khim., 1990, vol. 34, no. 5, p. 1337.
Turova, N.Ya. and Yanovskaya, M.I., Synthesis of Hydroxyapatite Crystals, Izv. Akad. Nauk SSSR, Neorg.Mater., 1983, vol. 19, no. 5, p. 693.
Hench, L.L., Bioceramics and the Future, Ceramics and Society, Brook, R.J., Ed., Faenza: Techna, 1995.
Zhang, S. and Gonsalves, K.E., Preparation and Characterization of Thermally Stable Nanohydroxyapatite, J. Mater. Sci.: Mater. Med., 1997, vol. 8, no. 8, pp. 25–28.
Elliort, J.C., Structure and Chemistry of the Apatites and Other Calcium Orthophosphates, Amsterdam: Elsevier, 1994.
Dubok, V.A. and Ul'yanin, N.V., Synthesis, Properties, and Applications of Osteotropic Substitute Materials Based on Hydroxyapatite Ceramics, Ortop., Travmatol.Protez., 1998, vol. 6, no. 3, pp. 26–30.
Feenstra, L. and de Groot, K., Bioceramics of Calcium Phosphate, Boca Raton: CRC, 1983.
Jarcho, M., Bolen, C.H., Thomas, M.B., et al., Synthesis and Characterization in Dense Polycrystalline Form, J. Mater. Sci., 1976, vol. 11, no. 10, p. 2027.
Yubao, L., de Groot, K., de Wijn, J., et al., Morphology and Composition of Nanograde Calcium Phosphate Needle-like Crystals Formed by Simple Hydrothermal Treatment, J. Mater. Sci.: Mater. Med., 1994, vol. 5, pp. 326–331.
Yubao, L., Klein, C.P., de Wijn, J., et al., Shape Change and Phase Transition of Needle-like Non-Stoichiometric Apatite Crystals, J. Mater. Sci.: Mater. Med., 1991, vol. 2, no. 1, pp. 51–55.
Orlovskii, V.P., Ionov, S.P., and Rusakova, R.A., Hydroxyapatite Phase Relations in the System CaCl2–(NH4)2HPO4–NH4OH–H2O, Dokl. Akad. Nauk, 1992, vol. 325, no. 5, p. 522.
Orlovskii, V.P. and Ionov, S.P., Synthesis of Hydroxyapatite in the System CaCl2–(NH4)2HPO4–NH4OH–H2O, Zh. Neorg. Khim., 1995, vol. 40, no. 12, p. 1961.
Vincent, J., Structural Biomaterials, Princeton: Princeton Univ. Press, 1990.
Kelly, A., Strong Solids, London: Oxford Univ. Press, 1971. Translated under the title Vysokoprochnye materialy, Moscow: Mir, 1976.
Hosoi, K., Hashida, T., Takahashi, H., et al., New Processing Technique for Hydroxyapatite Ceramics by the Hydrothermal Hot-Pressing Method, J. Am. Ceram.Soc., 1996, vol. 80, no. 10, pp. 2771–2774.
Hench, L.L., Bioceramics: From Concept to Clinic, J.Am. Ceram. Soc., 1991, vol. 75, no. 7, pp. 1487–1510.
LeGeros, R.Z., Biodegradation and Bioresorption of Calcium Phosphate Ceramics, J. Clin. Mater., 1993, vol. 35, no. 14, p. 65.
De With, G., Van Dijk, H.J.A., Hattu, N., and Prijs, K., Preparation, Microstructure, and Mechanical Properties of Dense Polycrystalline Hydroxyapatite, J. Mater. Sci., 1981, vol. 16, no. 7, pp. 1592–1598.
Hech, L.L., Bioceramics, J. Am. Ceram. Soc., 1998, vol. 82, no. 7, pp. 1705–1733.
Ruys, A.J., Wei, M., Sorrell, C.C., et al., Sintering Effects on Strength of Hydroxyapatite, Biomaterials, 1995, vol. 16, no. 5, pp. 409–415.
Wang, P.E. and Chaki, T.K., Sintering Behavior and Mechanical Properties of Hydroxyapatite and Dicalcium Phosphate, J. Mater. Sci.: Mater. Med., 1993, vol. 4, no. 3, pp. 150–158.
Cuneyt Tas, A., Korkusuz, E., Timucin, M., and Akkas, N., An Investigation of the Chemical Synthesis and High Temperature Sintering Behavior of Calcium HA and Tricalcium Phosphate Bioceramics, J. Mater.Sci.: Mater. Med., 1997, vol. 8, no. 2, pp. 91–96.
Fateeva, L.V., Golovkov, Yu.M., Barinov, S.M., et al., Effect of Sodium Phosphate on the Sintering Behavior of Hydroxyapatite Ceramics, Ogneupory Tekh. Keram., 2001, no. 1, p. 6.
Santos, J.D., Reis, R.L., Monteiro, F.J., et al., Liquid Phase Sintering of Hydroxyapatite by Phosphate and Silicate Glass Additions: Structure and Properties of the Composites, J. Mater. Sci.: Mater. Med., 1995, vol. 6, no. 4, p. 348.
Ratner, B.D., New Ideas in Biomaterials Sciences—Path to Engineering Biomaterials, J. Biomed. Mater.Res., 1993, vol. 27, no. 6, pp. 837–850.
Solov'ev, M.M., Ivasenko, I.N., Alekhova, T.M., et al., Effect of Hydroxyapatite on Cavity Healing in Carious Teeth, Stomatologiya, 1992, nos. 3–6, pp. 8–10.
Hupp, J.R. and Me Kenna, S.J., Use of Porous Hydroxylapatite Blocks for Augmentation of Atrophic Mandibles, J. Oral Maxillofac. Surg., 1998, no. 7, pp. 538–545.
Stahe, S.S. and Frourn, S.J., Histologic and Clinical Responses to Porous Hydroxylapatite Implants in Human Periodontal Defects: Three to Twelve Months Postimplantation, J. Periodontol., 1987, no. 10, pp. 689–695.
Uchida, A., Nade, S., Eric, M., and Ching, W., Bone Ingrowth into Three Different Porous Ceramics Implanted into the Tibia of Rats and Rabbits, J. Orthop.Res., 1985, no. 3, pp. 65–77.
Uchida, A., Shinto, Y., Araki, N., and Ono, K., Slow Release of Anticancer Drugs from Porous Calcium Hydroxyapatite Ceramic, J. Orthop. Res., 1992, no. 10, pp. 440–445.
Slosarzyk, A., Stobierska, E., and Paszkiewicz, Z., Porous Hydroxyapatite Ceramics, J. Mater. Sci. Lett., 1999, vol. 19, no. 18, p. 1163.
Yamasaki, N., Kai, T., Nishioka, M., et al., Porous Hydroxyapatite Ceramics Prepared by Hydrothermal Hot-Pressing, J. Mater. Sci. Lett., 1990, vol. 10, no. 10, p. 1150.
Tanner, K.E., Downes, R.N., and Bonfield, W., Clinical Application of Hydroxyapatite Reinforced Polyethylene, Br. Ceram. Trans. J., 1994, no. 3, pp. 104–107.
Liu, D., Preparation and Characterization of Porous HA Bioceramic via a Slip-Casting Route, J. Ceram. Int., 1997, vol. 24, no. 4, pp. 441–446.
Engin, N.O. and Tas, A.C., Preparation of Porous Ca10(PO 4)6(OH)2 and bgr -Ca 3(PO4)2 Bioceramics, J.Am. Ceram. Soc., 2000, vol. 84, no. 7, pp. 1581–1584.
Sepulveda, P., Ortega, F.S., and Murilo, D.M., Properties of Highly Porous Hydroxyapatite Obtained by the Gel Casting of Foams, J. Am. Ceram. Soc., 2000, vol. 3, no. 12, pp. 3021–3024.
Komlev, V.S., Barinov, S.M., Orlovskii, V.P., and Kurdyumov, S.G., Porous Hydroxyapatite Ceramics with a Bimodal Pore Size Distribution, Ogneupory Tekh. Keram., 2001, no. 6, pp. 23–25.
Donath, K., Relation of Tissue to Calcium Phosphate Ceramics, Osseous, 1991, vol. 1, p. 100.
Durucan, C. and Brown, P.W., α-Tricalcium Phosphate Hydrolysis to Hydroxyapatite at and near Physiological Temperature, J. Mater. Sci.: Mater. Med., 2000, vol. 11, no. 6, p. 365.
Krasulin, Yu.L., Barinov, S.M., and Ivanov, V.S., Struktura i razrushenie materialov iz poroshkov tugoplavkikh soedinenii (Structure and Fracture of Materials Prepared from Powders of Refractory Compounds), Moscow: Nauka, 1985.
Andrievskii, R.A., Strength of Sintered Bodies, Poroshk. Metall. (Kiev), 1982, no. 1, p. 37.
Metsger, D.S., Rieger, M.R., and Foreman, D.W., Mechanical Properties of Sintered Hydroxyapatite and Tricalcium Phosphate Ceramic, J. Mater. Sci.: Mater.Med., 1999, vol. 10, no. 1, p. 9.
Hing, K.A., Best, S.M., and Bonfield, W., Characterization of Porous Hydroxyapatite, J. Mater. Sci.: Mater.Med., 1999, vol. 10, no. 3, pp. 135–145.
Tas, A.C. and Ozgur Engin, N., Manufacture of Macroporous Calcium Hydroxyapatite Bioceramics, J.Eur. Ceram. Soc., 1999, vol. 19, no. 13/14, p. 2569.
Nakajima, T., Ichiro Ono, M.D., and Tohru Tateshita, M.D., Porous Hydroxyapatite Ceramics and Their Ability to Be Fixed by Commercially Available Screws, Biomaterials, 1999, vol. 20, no. 17, p. 1595.
Roncari, E., Galassi, C., and Pinasco, P., Tape Casting of Porous Hydroxyapatite Ceramics, J. Mater. Sci. Lett., vol. 20, no. 1, pp. 33–35.
Powers, J.M., Yaszemski, M.J., Thomson, R.C., and Mikos, A.G., Hydroxyapatite Fiber Reinforced Poly(ahydroxy ester) Foams for Bone Regeneration, Biomaterials, 1998, vol. 19, no. 21, pp. 1935–1943.
Yoshio Ota, Y., Iwashita, T., Kasuga, T., et al., Novel Preparation Method of Hydroxyapatite Fibers, J. Am.Ceram. Soc., 1998, vol. 81, no. 6, pp. 1665–1733.
Klassen, P.V. and Grishaev, I.G., Osnovy tekhniki granulirovaniya (Fundamentals of Granulation), Moscow: Khimiya, 1982.
Komlev, V.S., Barinov, S.M., and Fadeeva, I.V., Porous Hydroxyapatite Ceramic Granules for Drug Delivery Systems, Novye Tekhnol.–21 Vek, 2001, no. 5, pp. 18–19.
Komlev, V.S., Barinov, S.M., Orlovskii, V.P., and Kurdyumov, S.G., Porous Hydroxyapatite Ceramic Granules, Ogneupory Tekh. Keram., 2001, no. 5, pp. 18–20.
Gautier, H., Merle, C., Auget, J.L., and Daculsi, G., Isostatic Compression, a New Process for Incorporating Vancomycin into Biphasic Calcium Phosphate: Comparison with a Classical Method, Biomaterials, 2000, vol. 21, no. 2, pp. 243–249.
Kovalevskii, A.M., Surgical Treatment of Generalized Parodontitis Using Biopolymers and Bioceramics: A Clinical–Experimental Investigation, Cand. Sci. (Med.) Dissertation, St. Petersburg, 1998.
Fedosenko, T.D., Application of Hydroxyapatite Preparations in Combined Therapy of Parodontopathy, Extended Abstract of Cand. Sci. (Med.) Dissertation, St.Petersburg, 1994.
Chernysh, V.F., Shutov, Yu.N., and Kovalevskii, A.M., New Methods in Parodontium Surgery, Parodontologiya, 1997, no. 4, pp. 19–23.
Dash, A.K. and Cudworth, G.C., Therapeutic Applications of Implantable Drug Delivery Systems, J. Pharmacol.Toxicol. Methods, 1998, no. 1, pp. 1–12.
Chien, Y.W., Novel Drug Delivery Systems, New York: Marcel Dekker, 1992, 2nd ed.
Lasserre, A. and Bajpai, P.K., Ceramic Drug-Delivery Devices, Crit. Rev. Therap. Drug Carrier Syst., 1998, no. 11, pp. 1–56.
Tyle, P., Drug Delivery Devices: Fundamentals and Applications, New York: Marcel Dekker, 1988.
Morrell, R., Handbook of Properties of Technical and Engineering Ceramics. Part 1: An Introduction for the Engineer and Designer, London: Her Majesty's Stationary Office, 1989.
Leont'ev, V.K., Volozhin, A.I., Kurdyumov, S.G., et al., Clinical Application of the New Preparations Gidroksiapol and Kolapol: First Results, Stomatologiya, 1995, no. 5, p. 69.
Komlev, V.S., Porous Hydroxyapatite Ceramics and Related Composites, Extended Abstract of Cand. Sci. (Eng.) Dissertation, Moscow: Inst. of Physicochemical Problems in Ceramic Science, Russ. Acad. Sci., 2001.
Dewith, G. and Gorbijn, A.T., Metal Fibre Reinforced Hydroxyapatite Ceramics, J. Mater. Sci., 1989, vol. 24, no. 14, pp. 3411–3415.
Tamari, N., Kondo, N., Mouki, M., et al., Effect of Calcium Fluoride Addition on Densification and Mechanical Properties of Hydroxyapatite–Zirconia Composite Ceramics, J. Ceram. Soc. Jpn., 1987, vol. 95, no. 8, p. 806.
Li, J., Forbreg, S., and Hermansson, L., Evaluation of the Mechanical Properties of Hot Isostatically Pressed Titania and Titania–Calcium Phosphate Composites, Biomaterials, 1991, vol. 12, no. 5, pp. 438–440.
Young-Min Kong, Y.M., Sona Kim, S., and Lee, S., Reinforcement of Hydroxyapatite Bioceramic by Addition of ZrO2 Coated with Al2O3, J. Am. Ceram. Soc., 1999, vol. 83, no. 11, p. 2963.
Towler, M.R. and Gibson, I.R., The Effect of Low Levels of Zirconia Addition of the Mechanical Properties of Hydroxyapatite, J. Mater. Sci. Lett., 2001, vol. 20, no. 18, p. 1719.
Bakos, D., Soldan, M., and Hernandez-Fuentes, I., Hydroxyapatite–Collagen–Hyaluronic Acid Composite, Biomaterials, 1999, vol. 20, no. 2, pp. 191–195.
Bonfield, W., Grynpas, M.D., Tully, A.E., et al., Hydroxyapatite Reinforced Polyethylene—a Mechanically Compatible Implant, Biomaterials, 1981, vol. 2, no. 1, pp. 137–156.
Dalby, M.J., Di Silvio, L., Harper, E.J., and Bonfield, W., In Vitro Evaluation of New Polymethylmethacrylate Cement Reinforced with Hydroxyapatite, J. Mater. Sci.: Mater. Med., 1999, vol. 10, no. 12, p. 793.
Ignjatovic, N. and Delijic, K., The Designing of Properties of Hydroxyapatite/Poly-L-lactide Composite Biomaterials by Hot Pressing, J. Zeit. Metal., 2001, vol. 92, no. 2, pp. 145–149.
Knepper, M., Moricca, S., and Milthorpe, B.K., Stability of Hydroxyapatite While Processing Short-Fibre Reinforced Hydroxyapatite Ceramics, Biomaterials, 1997, vol. 18, no. 23, p. 1523.
Di Silvio, L., Dalby, M., and Bonfield, W., In Vitro Response of Osteoblasts to Hydroxyapatite-Reinforced Polyethylene Composites, J. Mater. Sci.: Mater. Med., 1998, vol. 9, no. 12, pp. 845–848.
Wang, M., Bonfield, W., and Joseph, R., Hydroxyapatite– Polyethylene Composites for Bone Substitution: Effects of Ceramic Particle Size, Biomaterials, 1998, vol. 18, no. 24, pp. 2357–2366.
Watson, K.E., Tenhuisen, K.S., and Brown, P.W., The Formation of Hydroxyapatite–Calcium Polyacrylate Composites, J. Mater. Sci.: Mater. Med., 1999, vol. 10, no. 4, pp. 205–213.
Okuno, M. and Shikinami, Y., Bioresorbable Devices Made of Forged Composites of Hydroxyapatite (HA) Particles and Poly-L-lactide (PLLA): Part I: Basic Characteristics, Biomaterials, 1999, vol. 19, no. 9, p. 859.
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Orlovskii, V.P., Komlev, V.S. & Barinov, S.M. Hydroxyapatite and Hydroxyapatite-Based Ceramics. Inorganic Materials 38, 973–984 (2002). https://doi.org/10.1023/A:1020585800572
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DOI: https://doi.org/10.1023/A:1020585800572