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A Portrait of the Bcl-2 Protein Family: Life, Death, and the Whole Picture

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Abstract

The Bcl-2 family of proteins are important regulators of cell death. They are comprised of two opposing factions, the proapoptotic versus the antiapoptotic members. Both are required for normal development and cellular homeostasis of the immune system and other tissues. However, in certain circumstances they may participate in the development of disease.

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    Marc Pellegrini, Andreas Strasser & Andreas Strasser

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Pellegrini, M., Strasser, A. A Portrait of the Bcl-2 Protein Family: Life, Death, and the Whole Picture. J Clin Immunol 19, 365–377 (1999). https://doi.org/10.1023/A:1020598632068

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