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Evaluation of Pulmonary Vein Stenosis after Catheter Ablation of Atrial Fibrillation

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Cardiac Electrophysiology Review

Abstract

Pulmonary vein (PV) stenosis has emerged recently as an important issue in patients who received radiofrequency (RF) ablation of atrial fibrillation (AF). Serial pathophysiological responses, including thrombosis, metaplasia, proliferation and neovascularization, may lead to PV stenosis after RF energy application around or inside the PV ostia. The clinical manifestations of PV stenosis consist of chest pain, dyspnea, cough, hemoptysis, recurrent lung infection and pulmonary hypertension. Although PV stenosis can be asymptomatic, its severity may be related to the numbers of stenotic PVs, the degree and chronicity of PV stenosis. The incidence of PV stenosis (defined as luminal diameter reduction >50%) detected by spiral computer tomography scan or three dimensional magnetic resonance angiography was from 0 to 7% per PV after isolation of PVs from left atria. Furthermore, some patients may show late progression of PV stenosis during follow-up. The first choice of treatment for symptomatic PV stenosis is PV angioplasty with stenting; however, restenosis were reported occasionally. Several studies have analyzed the predictors of PV stenosis, and the results are controversial. However, the consensus for prevention of PV stenosis should include less energy application and the ablation site more close to the atrial site.

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References

  1. Haissaguerre M, Jais P, Shah DC, Takahashi A, Hocini M, Quiniou G, Garrigue S, Le Mouroux A, Le Metayer P, Clementy J. Spontaneous initiation of atrial fibrillation by ectopic beats originating from pulmonary veins. N Engl J Med 1998;339:659–666.

    Google Scholar 

  2. Chen SA, Hsieh MH, Tai CT, Tsai CF, Prakash VS, Yu WC, Hsu TL, Ding YA, Chang MS. Initiation of atrial fibrillation by ectopic beats originating from the pulmonary veins: electrophysiologic characteristics, pharmacological response and effects of radiofrequency ablation. Circulation 1999;100:1879–1886.

    Google Scholar 

  3. Taylor GW, Kay GN, Zheng X, Bishop S, Ideker RE. Pathological effects of extensive radiofrequency energy applications in the pulmonary veins in dogs. Circulation 2000;101:1736–1742.

    Google Scholar 

  4. Ravenel JG, McAdams HP. Pulmonary venous infarction after radiofrequency ablation for atrial fibrillation. Am J Roentgenol 2002;178:664–666.

    Google Scholar 

  5. Packer DL, Peterson LA, Monahan KH, Asirvatham S, Munger TM, Friedman PA, Hammill SC. Relationship between the degree of pulmonary vein narrowing and symptoms in pulmonary vein stenosis: Where is the symptoms threshold? PACE 2002;25:560 (abstr).

    Google Scholar 

  6. Tsao HM, Wu MH, Yu WC, Tai CT, Lin YK, Ding YA, Chang MS, Chen SA. Detection of pulmonary vein stenosis and pseudo-stenosis following catheter ablation of atrial fibrillation by magnetic resonance angiography. PACE 2002;25:560 (abstr).

    Google Scholar 

  7. Lin YK, Tai CT, Hsieh MS, Tsai CF, Yeh TGT, Yu WC, Hsu TL, Ding YA, Chang MS, Chen SA. Use of intracardiac echography guiding focal ablation of pulmonary vein and superior vena cava in patients with paroxysmal atrial fibrillation. PACE 2000;23:567 (abstr).

    Google Scholar 

  8. Yu WC, Hsu TL, Tai CT, Tsai CF, Hsieh MH, Lin WS, Lin YK, Tsao HM, Ding YA, Chang MS, Chen SA. Acquired pulmonary vein stenosis after radiofrequency catheter ablation of paroxysmal atrial fibrillation. J Cardiovasc Electrophysiol 2001;12:887–892.

    Google Scholar 

  9. Leite L, Asirvatham S, Hammill SC, Friedman PA, Munger TM, Shen WK, Packer DL. Clinical and electrophysiological predictors of pulmonary vein stenosis following radiofrequency catheter ablation for atrial fibrillation. PACE 2002;25:559 (abstr).

    Google Scholar 

  10. Packer DL, Asirvatham S, Monahan KH, Shen WK, Rea RF, Hammill SC. Progression of pulmonary vein stenosis in patients following focal atrial fibrillation ablation. Circulation 2001;104:2184 (abstr).

    Google Scholar 

  11. Cole CR, Dressing TJ, Marrouche NF, Bash D, Saad E, Perez-Lugones A, Balaban KW, Tchou P, Natale A. Late progression of pulmonary vein stenosis after atrial fibrillation ablation. PACE 2002;25:637 (abstr).

    Google Scholar 

  12. Ernst S, Quyang F, Goya M, Menke K, Vogtmann T, Antz M, Kuck KH. Does lower RFC temperature to avoid PV stenosis cause more arrhythmic relapse after selective PV isolation. PACE 2002;25:638 (abstr).

    Google Scholar 

  13. Gerstenfeld EP, Guerra P, Sparks PB, Hattori K, Lesh MD. Clinical outcome after radiofrequency catheter ablation of focal atrial fibrillation triggers. J Cardiovasc Electrophysiol 2001;12:900–908.

    Google Scholar 

  14. Haissaguerre M, Jais P, Shah DC, Garrigue S, Takahashi A, Lavergne T, Hocini M, Peng JT, Roudaut R, Clementy J. Electrophysiological end point for catheter ablation of atrial fibrillation initiated from multiple pulmonary venous foci. Circulation 2000;101:1409–1417.

    Google Scholar 

  15. Haissaguerre M, Shah DC, Jais P, Hocini M, Yamane T, Deisenhofer I, Chauvin M, Garrigue S, Clementy J. Electrophysiological breakthroughs from the left atrium to the pulmonary veins. Circulation 2000;102:2463–2465.

    Google Scholar 

  16. Arentz T, Jander N, Rosenthal JV, Blum T, Buerkle G, Kalusche D. Long-term follow-up in patients with refractory atrial fibrillation after pulmonary vein ablation using radiofrequency energy. PACE 2002;25:710 (abstr).

    Google Scholar 

  17. Robbins IM, Colvin EV, Doyle TP, Kemp WE, Loyd JE, McMahon WS, Kay GN. Pulmonary vein stenosis after catheter ablation of atrial fibrillation. Circulation 1998;98:1769–1775.

    Google Scholar 

  18. Driscoll DJ, Hesslein PS, Mullins CE. Congenital stenosis of individual pulmonary vein stenosis: Clinical spectrum and unsuccessful treatment by balloon dilatation. Am J Cardiol 1982;49:1767–1772.

    Google Scholar 

  19. Ernst S, Quyang F, Schneider C, Goya M, Vogtmann T, Baensch D, Schaumann A, Antz M, Kuck KH. Management of PV occlusion: Interventional strategies and results of follow-up. PACE 2002;25:708 (abstr).

    Google Scholar 

  20. Spray TL, Bridges ND. Surgical management of congenital and acquired pulmonary vein stenosis. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 1999;2:177–188.

    Google Scholar 

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Tsao, HM., Chen, SA. Evaluation of Pulmonary Vein Stenosis after Catheter Ablation of Atrial Fibrillation. Card Electrophysiol Rev 6, 397–400 (2002). https://doi.org/10.1023/A:1021132307986

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  • DOI: https://doi.org/10.1023/A:1021132307986

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