Abstract
The assignment of NMR resonances of lupane triterpenoids was refined by the example of 3O,28O-dinicotinoylbetulin, obtained by acylation of betulin. Hepatoprotective, antiulcer, antiinflammatory, reparative, and anti-HIV activities were found for the compound. In addition, it was demonstrated to have immunomodulatory activity, for the first time detected among lupane triterpenoids.
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Flekhter, O.B., Karachurina, L.T., Nigmatullina, L.R. et al. Synthesis and Pharmacological Activity of Betulin Dinicotinate. Russian Journal of Bioorganic Chemistry 28, 494–500 (2002). https://doi.org/10.1023/A:1021297600187
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DOI: https://doi.org/10.1023/A:1021297600187