Abstract
Mercury and other heavy metal poisoning, represent a problem that is more common than most physicians recognize. Such poisoning can also have far reaching import in the diagnosis and understanding of the patient's hormone status, especially in the aging individual. The diagnosis and treatment of mercury poisoning is a major key to the reversal of hormonal dysregulation, often seen in patients of any age. This paper reviews the important clinical connection between hormone dysregulation and mercury toxicity and offers suggestions for diagnosis and treatment.
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Drasch G, Wanghofer E, Roider G. Are blood, urine, hair and muscle valid biomonitors for the internal burden of men with the heavy metals mercury, lead and cadmium. Trace Elements Electrolytes 1997; 14: 116-123.
Drasch G, Schupp I, Hofl H, Reinke R, Roider, G. Mercury burden of human fetal and infant tissues. Eur J Pediatr 1994;153:607-610.
Eggleston, DW and Nylander, M. Correlation of dental amalgam with mercury in brain tissue. J Prosthetic Dentistry 1987;58:704-706.
Clarkson TW. The toxicology of mercury. Crit Rev Clin Lab Sci 1997;34:369-403.
Butterworth, RF, Gonce, M, Barbeau, A. Accumulation and removal of 203Hg in different regions of the rat brain. J Can Sci Neur 1978;5:397-400.
Lorsheider, FL, Vimy, MJ, Summers, AO, et al. The dental amalgam mercury controversy—inorganic mercury and the CNS; genetic linkage of mercury and antibiotic resistance in intestinal bacteria. Toxicology 1995;97:19-22.
Lorscheider, FL, Vimy, MJ, Summers, AO. Mercury exposure from “silver” tooth fillings: emerging evidence questions a traditional dental paradigm. FASEB J 1995;9:504-508.
Fernicola, C, Govoni, S, Coniglio, L, Trabucchi, M. Toxicologic hazards at the endocrine level of heavy metals. G Ital Med Lav 1985;7:175-180.
Weiner, JA, Nylander, M. The relationship between mercury concentration in human organs and different predictor variables. Sci Total Environ 1993;138:101-1125.
Bertherat, J, Bluet-Pajot, MT, Epelbaum, J. Neuroendocrine regulation of growth hormone. Eur J Enocrinol 1995;132:12-2.
Argente, J, Pozo, J, Chowen, JA. The growth hormone axis: control and effects. Horm Res 1996;45:9-11.
Hartman, ML, Veldhuis, JD, Thorner, MO. Normal control of growth hormone secretion. Horm Res 1993;40:37-47.
Gillies, G. Somatostatin:the neuroendocrine story. Trends in Pharm Sci 1997;18:87-95.
Thakore, JH, Dinan, TG. Growth hormone secretion: the role of glucocorticoids. Life Sci 1994;14:1083-1099.
Corpas, E, Harman, SM, Blackman, MR. Human growth hormone and human aging. Endocrine Reviews 1993;14:20-39.
Lamberts, SWJ, van den Beld, AW, van der Lely, AJ. The endocrinology of aging. Science 1997;278:419-424.
Finch, CE, Tanzi, RE. Genetics of aging. Science 1997;278:407-411.
Morrison, JH, Hof, PR. Life and death of neurons in the aging brain. Science 1997;278:412-419.
Whitley, RJ, Meikle, AW, Watss, NB. In: Tietz Textbook of Clinical Chemistry, Burtis, CA, Ashwood, ER, eds., W.B.Saunders Co., Philadelphia, PA, pp. 1660-1694 (1994).
Demers, L.A., In: Clinical Chemistry: Theory, Analysis, Correlation, Kaplan, LA, Pesce, AJ, eds., Mosby, St.Louis, Mo, pp. 849-866 (1996).
Sanaka, T, Shinobe, M, Ando, et al. IGF-1 as an early indicator of malnutrition in patients with end-stage renal disease. Nephron 1994;67:73-81.
Juul, A, Moller, S. IGF-1 in chronic liver disease: a marker of hepatocellular dysfunction, malnutrition and survival. Nutrition 1997;13:231-232.
ATSDR/EPA Priority List. Agency for Toxic Substances and Disease Registry. US Department of Health and Human Services, 1995.
Langworth, S, Elinder, CG, Gothe, et al. Biological monitoring of environmental and occupational exposure to mercury. Int Arch Occup Environ Health 1991;63:161-167.
Marchi, A, Piana, G. Amalgam and the toxicological risks of mercury. A review of the argument. Minerva Stomatol 1995;44:344-318.
Enestrom, S, Hultman, P. Does amalgam affect the immune system? A controversial issue. Int Arch Allergy Immunol 1995;106:180-203.
Schuurs, AH, Davidson, CL. Sources of mercury. Rev Belge Med Dent 1993;48:8-16.
Bjorkman, L, Sandborgh-Englund, G, Ekstrand, J. Mercury in saliva and feces after removal of amalgam fillings. Toxicol Applied Pharmacol 1997;144:156-162.
Hanson, M, Pleva, J. The dental amalgam issue. A review. Experientia 1991;47:9-22.
Skare, I, Engqvist, A. Human exposure to mercury and silver released from dental amalgam restorations. Arch. Environ. Health 1994;49:384-394.
Barregard, L. Biological monitoring of exposure to mercury vapor. Scand J Work Environ Health 1993;19:45-49.
Sallsten, G, Thoren, J, Barregaard, L, et al. Long-term use of nicotine chewing gum and mercury exposure from dental amalgam fillings. J Dent Res 1996;75:594-598.
Schutte, NP, Knight, AL, Jahn, O. Mercury and Its Compounds. In: Occupational Medicine, 3rd Ed., C. Zenz, ed., Mosby, St. Louis, MO, 1994, pp.549-557.
Watanabe, C, Satoh, H. Evolution of our understanding of methylmercury as a health threat. Environ Health Perpec 1996;104:367-379.
Chemical Engineering News, June 16, 1997;75(24):11.
Ferracane, JL, Adey, JD, Nakajima, H, et al. Mercury vaporization from amalgams with varied alloy compositions. J. Dent Res 1995;74:1414-1417.
Katz, SA, Katz, RB, Use of hair analysis for evaluating mercury intoxication of the human body: a review. J Applied Toxicology 1992;12:79-84.
Certisimo, AJ, O'Connor, RP. Oral electricity. Gen Dent 1996;44:324-326.
Williamson, R. Clinical management of galvanic current between gold and amalgam. Gen Dent 1996:44:70-73.
Goyer, RA. Toxic and essential metal interactions. Annu Rev Nutr 1997;17:37-50.
Molin, M, Bergman, B, Marklund, SL, et al. Mercury, selenium and glutathione peroxidase before and after amalgam removal in man. Acta Odontol Scand 1990;48:189-202.
Pollard, KM, Hultman, P. Effects of mercury on the immune system. Metal Ions Biol Syst 1997;34:421-440.
Duhr, EF, Pendergrass, JC, Slevin JT, et al. HgEDTA complex inhibits GTP interactions with the E-site of brain beta-tubulin. Toxicol Appl Pharmacol 1993;122:273-280.
Pendergrass, JC, Haley, BE, Vimy, MJ, et al. Mercury vapor inhalation inhibits binding of GTP to tubulin in rat brain: similarity to a molecular lesion In Alzheimer diseased brain, Neurotoxicology. 1997;18:315-324.
Pendergrass, JC, Haley, BE. Inhibition of brain tubulin-guanosine 5'-triphosphate interactions by mercury: similarity to observations in Alzheimer's diseased brain, Met Ions Biol Syst 1997;34:461-478.
Magos, L. The effects of dimercaptosuccinic acid on the excretion and distribution of mercury in rats and mice treated with mercuric chloride and methylmercury chloride. Br J Pharmac 1976;56:479-484.
Cox, C, Clarkson, TW, Marsh, DO, et al. Dose-response analysis of infants prenatally exposed to methyl mercury: an application of a single compartment model to single-strand hair analysis. Environ Res 1989;49:318-332.
Chai, C, Feng, W, Qian, Q, et al. Total and methyl mercury levels in human scalp hairs of typical populations in China by NM, GC(EC), and other techniques. Biol Trace Elem Res 1994;43-45:423-433.
Hatch, WR, Ott, WL. Anal Chem 1968;40:2085.
Olesik, JW. Elemental analysis using ICP-OES and ICP-MS. An evaluation and assessment of remaining problems. Anal Chem 1991;63:12A-21A.
Roels, HA, Boeckx, M, Ceulemans, E, et al. Urinary excretion of mercury after occupational exposure to mercury vapour and influence of the chelating agent meso-2,3-dimercaptosuccinic acid (DMSA), British J Industrial Medicine 1991;48:247-253.
Goyer, RA, Cherian, MG, Jones, MM, et al. Role of chelating agents for prevention, intervention, and treatment of exposures to toxic metals. Environmental Health Perspectives 1995;103:1048-1052.
Kostial, K, Blanusa, M, Piasek, M, et al. Monoisoamyl and Mono-n-hexyl meso-2,3-dimercaptosuccinate in mobilizing 203Hg retention in relation to age of rats and route of administration. J Applied Toxicology 1995;15:201-206.
Louwerse, ES, Buchet, JP, Van Dijk, MA, et al. Urinary excretion of lead and mercury after oral administration of meso-2,3-dimercaptosuccinic acid in patients with motor neuron disease. Int Arch Occup Environ Health 1995;67:135-138.
Englund GS, Dahlqvist R, Lindelof B, et al. DMSA administration to patients with alleged mercury poisoning from dental amalgams: a placebo-controlled study. J Dent Res 1994;73:620-628.
Gale, GR, Smith, AB, Jones, MM, et al. Meso-2,3-dimercaptosuccinic acid monoalkyl esters: effects on mercury levels in mice. Toxicology 1993;81:49-56.
Aeseth, J, Jacobsen, D, Andersen, O, et al. Treatment of mercury and lead poisonings with dimercaptosuccinic acid and sodium dimercaptopropanesulfonate. Analyst 1995;120:853-854.
Keith, RL, Setiarahardjo, I, Fernando, Q, et al. Utilization of renal slices to evaluate the efficacy of chelating agents for removing mercury from the kidney. Toxicology 1997;116:67-75.
Lee, BK, Schwartz, BS, Stewart, W, et al. Provocative chelation with DMSA and EDTA: evidence for differential access to lead storage sites. Occup Environ Med 1995;52:13-19.
Aposhian, HV, Maiorino, RM, Gonzalez-Ramirez, D, et al. Mobilization of heavy metals by newer, therapeutically useful chelating agents. Toxicology 1995;97:23-38.
Aposhian, HV, Aposhian, MM. Meso-2,3-dimercaptosuccinic acid: chemical, pharmacological and toxicological properties of an orally effective metal chelating agent. Ann Rev Pharmacol Toxicol 1990;30:279-306.
Chemet (succimer), In: Physicians Desk Reference 1998;52:2568-2569.
Goyer, RA. Chelation of toxic metals: current interests. Environ Health Persp 1995;11:988-989.
Lifshitz, M, Hashkanazi, R, Phillip, M. The effect of 2,3 dimercaptosuccinic acid in the treatment of lead poisoning in adults. Ann Med 1997;29:83-85.
Dental amalgam. In: American Dental Association Principles of Ethics and Code of Professional Conduct, III.5.A.1, 1996.
Special report: When your patients ask about mercury in amalgam. J Amer Dent Assoc 1990;120:395-398.
Current amalgam status and restrictions world-wide. In: Heavey Metal Bulletin, M Kauppi, (ed.) 1996, volume 3.
The International Academy of Oral Medicine and Toxicology (IAOMT) (phone: 407-298-2450) and The Academy of Biological Dentistry (408-659-5385).
Mariotti, S, Fanceshi, C, Cossariza, A, et al. The aging thyroid, Endocrine Reviews 16:686-715(1995).
Frohman, LA, Downs, TR, Kelijman, M, et al. Somatostatin secretion and action in the regulation of growth hormone secretion. Metabolism 1990;3543-45.
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OH and a past President of American College for Advancement in Medicine.
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Frackelton, J.P., Christensen, R.L. Mercury Poisoning and Its Potential Impact on Hormone Regulation and Aging: Preliminary Clinical Observations Using a New Therapeutic Approach . Journal of Advancement in Medicine 11, 9–25 (1998). https://doi.org/10.1023/A:1023373303542
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DOI: https://doi.org/10.1023/A:1023373303542