Abstract
Sonogashira cross-coupling of 3-chloro-6,8-dimethylpyrimido[4,5-c]pyridazine-5,7(6H,8H)-dione with terminal alkynes afforded the corresponding 3-(alkyn-1-yl) derivatives. Oxidative amination of the latter compounds with primary alkylamines was accompanied by heterocyclization to give 6,8-dimethylpyrrolo[3",2":3,4]pyrimido[4,5-c]pyridazine-7,9(6H,8H)-diones.
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Gorunenko, V.V., Gulevskaya, A.V. & Pozharskii, A.F. Purines, pyrimidines, and related fused systems. 19. Use of S N H methodology for the synthesis of a new heterocyclic system, pyrrolo[3",2":3,4]pyrimido[4,5-c]pyridazine. Russian Chemical Bulletin 52, 441–446 (2003). https://doi.org/10.1023/A:1023431504814
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DOI: https://doi.org/10.1023/A:1023431504814