Skip to main content
Log in

Contractile Activity of Human Greater Saphenous Vein Mediated by P2-Receptors

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

In vitro experiments were carried out to measure the contractile responses to P2-receptor agonists in the greater saphenous vein isolated from patients with obliterating vascular atherosclerosis and varicose veins of the legs. In patients with varicose veins, the contractile responses of the greater saphenous vein to ATP, α,β-methylene-ATP, and UTP were significantly lower than in patients with obliterating atherosclerosis, while the responses to ADP, adenosine, and 2-methylthio-ATP were similar in both groups. These data attest to the presence of P2-receptor-mediated contraction component in the greater saphenous vein, which are pronouncedly weakened during varicose disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. A. U. Ziganshin and L. E. Ziganshina, Pharmacology of ATP Receptors [in Russian], Moscow (1999).

  2. A. U. Ziganshin, L. E. Ziganshina, A. V. Rychkov, et al., Eksp. Klin. Farmakol., No. 4, 27–30 (2001).

  3. M. P. Abbracchio and M. Williams, in: Handbook of Experimental Pharmacology. Purinergic and Pyrimidinergic Signaling, Eds. M. P. Abbrachio and M. Williams, Vol. 151, Pt. 1, Berlin (2001), pp. 1–16.

  4. M. R. Boarder and S. M. O. Hourani, Trends Pharmacol. Sci., 19, 99–107 (1998).

    Google Scholar 

  5. G. Burnstock, Ibid., 22, 182–188 (2001).

    Google Scholar 

  6. S. P. Kunapuli and J. L. Daniel, Biochem. J., 336, 513–523 (1998).

    Google Scholar 

  7. A. Pelleg and G. Vassort, in: Handbook of Experimental Pharmacology. Purinergic and Pyrimidinergic Signaling, Eds. M. P. Abbrachio and M. Williams, Vol. 151, Pt. 2, Berlin (2001), pp. 73–99.

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to A. U. Ziganshin.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ziganshin, A.U., Khaziakhmetov, D.F., Ziganshina, L.E. et al. Contractile Activity of Human Greater Saphenous Vein Mediated by P2-Receptors. Bulletin of Experimental Biology and Medicine 135, 23–25 (2003). https://doi.org/10.1023/A:1023477324977

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1023477324977

Navigation