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Serum Prolactin and TSH in an In Vitro Fertilization Population: Is There a Link Between Fertilization and Thyroid Function?

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Abstract

Purpose : Measurements of TSH and prolactin are generally included in the evaluation of female infertility, but their value in women coming to in vitro fertilization (IVF) has been questioned.

Methods : In this study, we sought to investigate whether prolactin or TSH, measured in 509 specimens collected prior to therapy, predicted outcome in a prospective study of couples undergoing IVF between 1994 and 2001.

Results : TSH was higher in women whose fertility problem was attributed to a male factor, and prolactin was lower if the measurement was taken during menses. TSH and prolactin were positively correlated (p < 0.0001). Neither TSH nor prolactin levels correlated with overall IVF outcome; however, TSH levels were significantly higher among women who produced oocytes that failed to be fertilized and this finding persisted after adjustment for several covariates, including sperm motility. Among women who had a least one oocyte inseminated, the likelihood that they would have fewer than 50% of their eggs fertilized was significantly related to higher TSH levels in a multivariate model.

Conclusion : We conclude that TSH may predict poor fertilization in IVF and reflect the importance of thyroid hormones in oocyte physiology.

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References

  1. Glatstein IZ, Harlow BL, Hornstein MD: Practice patterns among reproductive endocrinologists: The infertility evaluation. Fertil Steril 1997;67:443-451

    Google Scholar 

  2. Conway DJ, Glazener CMA, Kelly N, Hull MGR: Routine measurement of thyroid hormones and FSH in infertility not worthwhile. Lancet 1985;1:977-978

    Google Scholar 

  3. Laufer MR, Floor AE, Parsons KE, Kuntz KM, Barbieri RL, Friedman AJ: Evaluation of hormonal testing in the screening for in vitro fertilization (IVF) of women with tubal factor infertility. J Assist Reprod Genet 1995;12:93-96

    Google Scholar 

  4. Zollner U, Lanig K, Steck T, Dietl J: Assessment of endocrine status in-patients undergoing in-vitro fertilization treatment. Is it necessary? Arch Gynecol Obstet 2001;265:16-20.

    Google Scholar 

  5. Inzucchi SE, Burrow GN: The thyroid gland and reproduction. In Reproductive Endocrinology, SSC Yen, RB Jaffe, RL Barbieri (Eds), Philadelphia, W.B. Saunders, 1999, pp 413-435

    Google Scholar 

  6. Wakim AN, Polizotto SL, Burholt DR: Influence of thyroxine on human granulosa cell steroidogenesis in vitro. J Assist Reprod Genet 1995;12:274-277

    Google Scholar 

  7. Krassas GE, Pontikides N, Kaltsas T, Papadoupoulou P, Batrinos M: Menstrual disturbance in thyrotoxicosis. Clin Endocrinol 1994;40:641-644

    Google Scholar 

  8. Vekemans M, Delvoye P, L'Hermite M, Robyn L: Serum prolactin levels during the menstrual cycle. J Clin Endocrinol Metab 1977;44:989-993

    Google Scholar 

  9. Younis AI, Brackett BG: Thyroid stimulating hormone enhancement of bovine oocyte maturation in vitro. Mol Reprod Dev 1992;31:144-151

    Google Scholar 

  10. Younis AI, Sehgal PK, Biggers JD: Antral follicle development and in-vitro maturation of oocytes from macaques stimulated with a single injection of pregnant mare's serum gonadotropins. Hum Reprod 1994;9:2130-2134

    Google Scholar 

  11. Upadhyaya N, Haider S: Germinal vesicle breakdown in oocytes of catfish, Mystus vittatus: In vitro effectiveness of mammalian pituitary hormones. Gen Comp Endocrinol 1987;65:496-500

    Google Scholar 

  12. Keskintepe L, Darwish GM, Younis AI, Brackett BG: In vitro development of morulae from immature caprine oocytes. Zygote 1994;2:97-102

    Google Scholar 

  13. Zhang SS, Carrillo AJ, Darling DS: Expression of multiple thyroid receptor mRNAs in human oocytes, cumulus cells, and granulosa cells. Mol Hum Reprod 1997;3:555-562

    Google Scholar 

  14. Ritchie JW, Peter GJ, Shi YB, Taylor PM: Thyroid hormone transport by 4F2hc-IU12 heterodimers expressed in Xenopus oocytes. J Endocrinol 1999;163:R5-R9

    Google Scholar 

  15. Friesema EC, Docter R, Krenning EP, Everts ME, Hennemen G, Visser TJ: Rapid sulfation of 3,3′,5′-triiodothyronine in native Xenopus laevis oocytes. Endocrinology 1998;139:596-600

    Google Scholar 

  16. Detlaf TA, Davydova SI: The effect of triiodothyronine on oocyte maturation in the starred sturgeon following exposure to low temperatures and female reservation. Ontogenez 1974;5:454-462

    Google Scholar 

  17. Jiang JY, Miyoshi K, Umeza M, Sato E: Superovulation of immature hypothyroid rdw rats by thyroxine therapy and the development of eggs after in-vitro fertilization. J Reprod Fertil 1999;116:19-24

    Google Scholar 

  18. Emperaire JC, Gauzere E, Audebert A: Female fertility and donor insemination. Lancet 1980;1:1423-1424

    Google Scholar 

  19. Albrecht BH, Cramer DW, Schiff I: Factors influencing the success of artificial insemination. Fertil Steril 1982;37:792-797

    Google Scholar 

  20. Haddow JE, Palomaki GE, Allan WC, Williams JR, Knight GJ, Gagnon J, O'Heir CE, Mitchell ML, Hermos RJ, Waisbren SE, Faix JD, Klein RZ: Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Engl J Med 1999;341:549-555

    Google Scholar 

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Authors and Affiliations

  1. Ob-Gyn Epidemiology Center, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, Massachusetts, 02115

    D. W. Cramer & A. F. Vitonis

  2. Reproductive Endocrinology Unit Laboratory, Department of Obstetrics and Gynecology, Fruit Street Massachusetts General Hospital, Boston, Massachusetts

    P. M. Sluss

  3. Boston IVF, Waltham, Massachusetts

    R. D. Powers

  4. Reproductive Science Center, Deaconess–Waltham Hospital, Waltham, Massachusetts

    P. McShane

  5. Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Boston, Massachusetts

    E. S. Ginsburg, M. D. Hornstein & R. L. Barbieri

Authors
  1. D. W. Cramer
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  2. P. M. Sluss
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  3. R. D. Powers
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  4. P. McShane
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  5. E. S. Ginsburg
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  6. M. D. Hornstein
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  7. A. F. Vitonis
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  8. R. L. Barbieri
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Cramer, D.W., Sluss, P.M., Powers, R.D. et al. Serum Prolactin and TSH in an In Vitro Fertilization Population: Is There a Link Between Fertilization and Thyroid Function?. J Assist Reprod Genet 20, 210–215 (2003). https://doi.org/10.1023/A:1024151210536

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