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The Role of C/EBPβ in Mammary Gland Development and Breast Cancer

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Journal of Mammary Gland Biology and Neoplasia Aims and scope Submit manuscript

Abstract

The CCAAT/enhancer binding protein (C/EBP) family of bZIP transcription factors control the proliferation and differentiation of a variety of tissues. While C/EBPα and -∂ are also expressed in the mammary gland, the multiple protein isoforms of C/EBPβ appear to play a critical role in mammary gland development and breast cancer. Targeted deletion of all the C/EBPβ isoforms results in a severe inhibition of lobuloalveolar development and a block to functional differentiation, as well as more subtle changes in ductal morphogenesis. The altered expression of a number of molecular markers, including the progesterone, estrogen, and prolactin receptors, the transporter proteins (NKCC1 and aquaporin 5), and several markers of skin differentiation (Sprr2A and keratin 6), suggests that germline deletion of C/EBPβ results in an altered cell fate. Thus, C/EBPβ appears to play a role in the specification of progenitor cell fate not only in the mammary gland, but also in a number of other tissues.

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  1. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas

    Sandra L. Grimm & Jeffrey M. Rosen

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Grimm, S.L., Rosen, J.M. The Role of C/EBPβ in Mammary Gland Development and Breast Cancer. J Mammary Gland Biol Neoplasia 8, 191–204 (2003). https://doi.org/10.1023/A:1025900908026

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