Abstract
4-Amino-3-hydroxybutyric acid was synthesized from allyl cyanide in four steps in an overall yield of 38%. Ultrasonically promoted epoxidation of allyl cyanide with m-chloroperoxybenzoic acid giving oxiranylacetonitrile was used as a key step.
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Mete, E., Maraş, A. & Seçen, H. A short synthesis of 4-amino-3-hydroxybutyric acid (GABOB) via allyl cyanide. Russian Chemical Bulletin 52, 1879–1881 (2003). https://doi.org/10.1023/A:1026045829876
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DOI: https://doi.org/10.1023/A:1026045829876