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A Specific Role for Cyclin D1 in Mammary Gland Development

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Abstract

Cyclin D1 is a critical component of the core cell cycle machinery. Mice lacking cyclin D1 develop mammary glands that fail to undergo normal lobuloalveolar proliferation during pregnancy. Thus, cyclin D1 seems to play a critical role in pregnancy-induced proliferation of mammary epithelium. Cyclin D1 also participates in neoplasia, as the majority of human mammary carcinomas contain elevated levels of this cyclin.

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  1. Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02142

    Piotr Sicinski & Robert A. Weinberg

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  1. Piotr Sicinski
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  2. Robert A. Weinberg
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Sicinski, P., Weinberg, R.A. A Specific Role for Cyclin D1 in Mammary Gland Development. J Mammary Gland Biol Neoplasia 2, 335–342 (1997). https://doi.org/10.1023/A:1026391128117

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