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Studies on gelatin-based sponges. Part III: A comparative study of cross-linked gelatin/alginate, gelatin/hyaluronate and chitosan/hyaluronate sponges and their application as a wound dressing in full-thickness skin defect of rat

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Abstract

Novel cross-linked sponges composed of gelatin/alginate and gelatin/hyaluronate and chitosan/hyaluronate (GH, GA and CH, respectively) were prepared and compared. Six different sponges with or without silver sulfadiazine (AgSD) were applied on the full-thickness dorsal skin defect of Wistar rat. The histology and epidermal wound healing rates of the skin defects were investigated by light microscopy and computerized morphometry 5 and 12 days post-operatively. In our full-thickness wound model (diameter 1 cm), the AgSD-impregnated sponges showed good wound healing performances on the whole. However, there appeared meaningful differences of wound healing between the gelatin-based sponges (GH, GA) and the CH. GH with AgSD was found to show the best wound healing properties as a wound dressing resulting from histological findings and computerized morphometric analysis of epidermal healing.

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Authors and Affiliations

  1. Department of Industrial Chemistry, College of Engineering, South Korea

    Y. S. Choi, S. B. Lee, S. R. Hong & Y. M. Lee

  2. Department of Pathology, College of Medicine, Hanyang University, Seoul, 133–791, South Korea

    K. W. Song & M. H. Park

Authors
  1. Y. S. Choi
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  2. S. B. Lee
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  3. S. R. Hong
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  4. Y. M. Lee
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  5. K. W. Song
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  6. M. H. Park
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Correspondence to S. B. Lee.

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Choi, Y.S., Lee, S.B., Hong, S.R. et al. Studies on gelatin-based sponges. Part III: A comparative study of cross-linked gelatin/alginate, gelatin/hyaluronate and chitosan/hyaluronate sponges and their application as a wound dressing in full-thickness skin defect of rat. Journal of Materials Science: Materials in Medicine 12, 67–73 (2001). https://doi.org/10.1023/A:1026765321117

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