Skip to main content
Log in

Protein Structure from X-Ray Diffraction

  • Published:
Journal of Biological Physics Aims and scope Submit manuscript

Abstract

Protein crystallography is the study of the three-dimensional structures of proteins at near atomic resolution. It has provided at remendous insight into the workings of numerous biological processes over the last few decades. The field has undergone a massive worldwide expansion over the last ten years, not only in academic laboratories, but also in the pharmaceutical industry. The main driving force for this expansion has been the promise of using three-dimensional atomic structures of proteins and other macromolecules to design lead drugs and to improve the action of existing drugs.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bernal, J.D. and Crowfoot, D.: X-ray Photographs of Crystalline Pepsin, Nature 794 (1934), 133-134.

    Google Scholar 

  2. Kendrew, J.C., Dickerson, R.E., Strandberg, B.E., et al.: Structure of Myoglobin, Nature 185 (1960), 442-447.

    Article  Google Scholar 

  3. http://www.rscb.org/

  4. McPherson, A.: Crystallization of Biological Macromolecules, Cold Spring Harbor Laboratory Press, New York, 1999.

    Google Scholar 

  5. Luthy, R., Bowie, J.U. and Eisenberg, D.: Assessment of Protein Models with Three-Dimensional Profiles, Nature 356 (1992), 83-85.

    Article  ADS  Google Scholar 

  6. Erickson, J., Neidhart, D.J., VanDrie, J., et al.: Design, Activity, and 2.8 Å Crystal Structure of a C2 Symmetric Inhibitor complexed to HIV-1 Protease, Science 249 (1990), 527-533.

    ADS  Google Scholar 

  7. Appelt, K., Bacquest, R.J., Bartlett, C.A., et al.: Design of Enzyme Inhibitors using Iterative Protein Crystallographic Analysis, J. Med. Chem. 34 (1991), 1925-1934.

    Article  Google Scholar 

  8. Von Itzstein, M., Wu, W-Y., Kok, G.B., et al.: Rational Design of Potent Sialidase-Based Inhibitors of Influenza Virus Replication, Nature 363 (1993), 418-423.

    Article  ADS  Google Scholar 

  9. Hodgson, J.: Data-Directed Drug Design, Bio/Technology 9 (1991), 19-21.

    Article  Google Scholar 

  10. Nature 409 (2001), 15 February issue.

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Parker, M. Protein Structure from X-Ray Diffraction. Journal of Biological Physics 29, 341–362 (2003). https://doi.org/10.1023/A:1027310719146

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1027310719146

Keywords

Navigation