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OXYS Rats as a Model of Senile Cataract

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Abstract

Changes in the lens appear by the age of 2 months in early aging OXYS rats, at the age of 6 months these changes are detected in 100% animals, and by 12 months both eyes are involved. According to biomicroscopy findings, predominant forms of cataract are vesicular, annular, and dendritic, located in the cortical layer and/or nucleus of the lens. Light and electron microscopy showed morphological changes involving all structural components of the lens: epithelial degeneration progressing with age, deformation of fiber architectonics, and appearance of uneven condensations. Cataract in OXYS rats corresponds to senile cataract, which makes this rat strain a unique model for studies of the pathogenesis of involutive cataract and elaboration of methods for its prevention and correction.

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REFERENCES

  1. A. I. Deev and M. A. Bibizhaev, Biol. Membrany, 19, No. 5, 435-448 (2002).

    Google Scholar 

  2. N. G. Kolosova, S. V. Aidagulova, G. I. Nepomnyashchikh, et al., Byull. Eksp. Biol. Med., 132, No. 8, 235-240 (2001).

    Google Scholar 

  3. L. V. Loskutova and N. G. Kolosova, Ibid., 130, No. 8, 155-158 (2000).

    Google Scholar 

  4. L. M. Nepomnyashchikh, D. E. Semenov, N. A. Solov'eva, and R. I. Salganik, Ibid., 118, No. 11, 547-551 (1994).

    Google Scholar 

  5. N. A. Solov'eva, T. S. Morozkova, and R. I. Salganik, Genetika, 11, No. 5, 63-71 (1975).

    Google Scholar 

  6. D. L. Boyle, D. S. Blunt, and L. J. Takemoto, Exp. Eye Res., 64, No. 4, 565-572 (1997).

    Google Scholar 

  7. C. D. Freel, K. O. Gilliland, L. C. Wesley, et al., Ibid., 74, No. 6, 689-702 (2002).

    Google Scholar 

  8. M. Hosokawa, Y. Ashida, T. Tsuboyama, et al., Ibid., 47, No. 4, 629-640 (1988).

    Google Scholar 

  9. J. F. Kuck, Ibid., 50, No. 6, 659-664 (1990).

    Google Scholar 

  10. T. Okano, S. Uga, S. Ishikawa, and S. Shumiya, Ibid., 57, 567-576 (1993).

    Google Scholar 

  11. Inbred Strains of rats, Rat Genome, 2, No. 2, 52-54 (1996).

  12. R. I. Salganik, I. G. Shabalina, N. A. Solovyova, et al., Biochem. Biophys. Res. Commun., 205, No. 1, 180-185 (1994).

    Google Scholar 

  13. S. Shumiya and S. Nagase, Proc. Jpn. Ass. Animal Model. Human Dis., 4, 30 (1988).

  14. B. J. Tripathi, R. C. Tripathi, N. S. Borisuth, et al., Lens Eye Toxic Res., 8, No. 4, 373-413 (1991).

    Google Scholar 

  15. S. Uga and N. Ihara, Exp. Eye Res., 50, 665-670 (1990).

    Google Scholar 

  16. N. S. Wolf, Y. Li, W. Pendergrass, et al., Ibid., 70, 683-692 (2000).

    Google Scholar 

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Authors and Affiliations

  1. Siberian Division of Russian Academy of Sciences, Institute of Cytology and Genetics, Novosibirsk

    N. G. Kolosova, P. A. Lebedev, S. V. Aidagulova & T. S. Morozkova

  2. Siberian Division of Russian Academy of Medical Sciences, State Institute of Regional Pathology and Pathomorphology, Novosibirsk

    N. G. Kolosova, P. A. Lebedev, S. V. Aidagulova & T. S. Morozkova

  3. Novosibirsk Affiliated Department of Moscow Research and Therapeutic Complex “Ocular Microsurgery”, Russia

    N. G. Kolosova, P. A. Lebedev, S. V. Aidagulova & T. S. Morozkova

Authors
  1. N. G. Kolosova
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  2. P. A. Lebedev
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  3. S. V. Aidagulova
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  4. T. S. Morozkova
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Correspondence to N. G. Kolosova.

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Kolosova, N.G., Lebedev, P.A., Aidagulova, S.V. et al. OXYS Rats as a Model of Senile Cataract. Bulletin of Experimental Biology and Medicine 136, 415–419 (2003). https://doi.org/10.1023/B:BEBM.0000010967.24302.78

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  • DOI: https://doi.org/10.1023/B:BEBM.0000010967.24302.78

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