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Effects of Flavonoids on the Resistance of Microsomes to Lipid Peroxidation In Vitro and Ex Vivo

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Abstract

Incubation of rat liver microsomes with preparations of grape flavonoids, dihydroquercetin, and silibinin increased their resistance to lipid peroxidation induced by NADPH-Fe2++. This was manifested in less pronounced accumulation of lipid peroxidation products and changes in activity of microsomal enzymes induced by lipid peroxidation. In vitro antioxidant activity of grape flavonoids markedly surpassed that of dihydroquercetin and silibinin. Addition of flavonoids into fodder led to moderate, statistically significant, and similar increase in the resistance of rat liver microsomes to ex vivo induced lipid peroxidation.

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REFERENCES

  1. V. K. Kolkhir, N. A. Tyukavkina, V. A. Bykov, et al., Khim.-Farm. Zh., No. 9, 61-64 (1995).

  2. L. V. Kravchenko, S. V. Morozov, and V. A. Tutel'yan, Byull. Eksp. Biol. Med., 136, No. 7, 76-79 (2003).

    Google Scholar 

  3. Yu. O. Teselkin, B. A. Zhambalova, I. V. Babenkova, et al., Biofizika, 41, No. 3, 620-623 (1996).

    Google Scholar 

  4. D. Bagchi, A. Garg, R. L. Krohn, et al., Res. Commun. Mol. Pathol. Pharmacol., 95, No. 2, 179-189 (1997).

    Google Scholar 

  5. D. Bagchi, C. K. Sen, S. D. Ray, et al., Mutat. Res., No. 523-524, 87-97 (2003).

  6. L. Bravo, Nutr. Rev., 56, No. 11, 317-322 (1998).

    Google Scholar 

  7. B. Burchell and P. Weatherill, Methods Enzymology, 77, 169-176 (1981).

    Google Scholar 

  8. W. Dehnen, R. Tomingas, and J. A. Roos, Anal. Biochem, 53, 373-383 (1973).

    Google Scholar 

  9. S. Deprez, C. Brezillon, S. Rabot, et al., J. Nutrition, 130, No. 11, 2733-2738 (2000).

    Google Scholar 

  10. F. Fraschini, G. Demartini, and D. Esposti, Clin. Drug Inv., 16, No. 1, 51-65 (2002).

    Google Scholar 

  11. R. R. Holt, S. A. Lazarus, M. C. Sullards, et al., Am. J. Clin. Nutr., 76, No. 4, 798-804 (2002).

    Google Scholar 

  12. J. Psotova, S. Chlopcikova, F. Grambal, et al., Phytother. Res., 16, No. 1, S63-S67 (2002).

    Google Scholar 

  13. S. V. Verstraeten, C. L. Keen, H. H. Schmitz, et al., Free Rad. Biol. Med., 34, No. 1, 84-89 (2003).

    Google Scholar 

  14. J. Zhao and R. Agarwal, Carcinogenesis, 20, No. 11, 2101-2108 (1999).

    Google Scholar 

  15. A. Ghiselli, M. Nardini, A. Baldi, and C. Scaccini, J. Agric. Chem., 46,361-367 (1998).

    Google Scholar 

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Authors and Affiliations

  1. Russian Academy of Medical Sciences, Institute of Nutrition, Moscow

    L. V. Kravchenko, S. V. Morozov & V. A. Tutel'yan

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  1. L. V. Kravchenko
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  2. S. V. Morozov
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  3. V. A. Tutel'yan
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Kravchenko, L.V., Morozov, S.V. & Tutel'yan, V.A. Effects of Flavonoids on the Resistance of Microsomes to Lipid Peroxidation In Vitro and Ex Vivo . Bulletin of Experimental Biology and Medicine 136, 572–575 (2003). https://doi.org/10.1023/B:BEBM.0000020207.67705.59

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  • DOI: https://doi.org/10.1023/B:BEBM.0000020207.67705.59

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