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Anti-fungal effects of phenolic amides isolated from the root bark of Lycium chinense

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Abstract

Four phenolic amides, dihydro-N-caffeoyltyramine (1), trans-N-feruloyloctopamine (2), trans-N-caffeoyltyramine (3), and cis-N-caffeoyltyramine (4), were isolated from an ethyl acetate extract of the root bark of Lycium chinense Miller. All had an anti-fungal effect; compounds 1-3 were potent at 5–10 μg ml−1 and were without hemolytic activity against human erythrocyte cells. Compound 4 was active at 40 μg ml−1. All four compounds impeded the dimorphic transition of pathogen, Candida albicans.

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Authors and Affiliations

  1. Department of Microbiology, Kyungpook National University, Daegu, 702-701, Republic of Korea

    Dong Gun Lee, Hyun Jun Jung & Young Bae Seu

  2. Research Center for Proteineous Materials, Republic of Korea

    Yoonkyung Park, Mi-Ran Kim, Kyung-Soo Hahm & Eun-Rhan Woo

  3. College of Pharmacy, Chosun University, Gwangju, 501-759, Republic of Korea

    Yoonkyung Park, Mi-Ran Kim, Kyung-Soo Hahm, Eun-Rhan Woo & Eun-Rhan Woo

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  1. Dong Gun Lee
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  2. Yoonkyung Park
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  3. Mi-Ran Kim
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  4. Hyun Jun Jung
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  5. Young Bae Seu
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  6. Kyung-Soo Hahm
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  7. Eun-Rhan Woo
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Lee, D.G., Park, Y., Kim, MR. et al. Anti-fungal effects of phenolic amides isolated from the root bark of Lycium chinense . Biotechnology Letters 26, 1125–1130 (2004). https://doi.org/10.1023/B:BILE.0000035483.85790.f7

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