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Synthesis and Immunostimulating Activity of Cysteine-Containing Derivatives of Glycyrrhizic Acid

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Abstract

New cysteine-containing derivatives of glycyrrhizic acid were synthesized by its coupling with Cys(Bzl) esters or the Cys(Bzl)-Val-OBut dipeptide by the active ester method (DCC/HOSu) or by Woodward's reagent K. The derivatives with Cys(Bzl) and Cys(Bzl)-Val residues attached to the carbohydrate part of the molecule stimulated the primary immune response and the reaction of delayed-Type hypersensitivity in mice at a dose of 2 mg/kg.

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Authors and Affiliations

  1. Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, pr. Oktyabrya 71, Ufa, Bashkortostan, 450054, Russia

    L. A. Baltina, E. V. Vasil'eva, L. A. Baltina Jr., A. F. Ismagilova, Kh. M. Nasyrov & G. A. Tolstikov

  2. Bashkortostan State Medical University, Ufa, Bashkortostan, 450074, Russia

    R. M. Kondratenko, N. Zh. Baschenko, R. M. Kireeva & S. M. Fridman

Authors
  1. R. M. Kondratenko
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  2. L. A. Baltina
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  3. E. V. Vasil'eva
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  4. L. A. Baltina Jr.
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  5. A. F. Ismagilova
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  6. Kh. M. Nasyrov
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  7. N. Zh. Baschenko
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  8. R. M. Kireeva
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  9. S. M. Fridman
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  10. G. A. Tolstikov
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Correspondence to L. A. Baltina.

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Kondratenko, R.M., Baltina, L.A., Vasil'eva, E.V. et al. Synthesis and Immunostimulating Activity of Cysteine-Containing Derivatives of Glycyrrhizic Acid. Russian Journal of Bioorganic Chemistry 30, 53–59 (2004). https://doi.org/10.1023/B:RUBI.0000015774.09619.80

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  • DOI: https://doi.org/10.1023/B:RUBI.0000015774.09619.80

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