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Synthesis and Immunomodulating Activity of New Amino Acid Derivatives of Glycyrrhizic Acid and Its Methyl Ester

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Abstract

New amino acid derivatives of glycyrrhizic acid and its methyl ester were selectively synthesized using active N-succinimide esters. The compounds with residues of glycine ethyl ester and alanine methyl and butyl esters increased the level of agglutinins and hemolysins in blood serum of mice two- to threefold in comparison with the control upon parenteral administration at a dose of 2 mg/kg for 14 days.

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Authors and Affiliations

  1. Ufa, Bashkortostan, 450074, Russia

    R. M. Kondratenko, Kh. M. Nasyrov, R. M. Kireeva, N. Zh. Baschenko, S. M. Fridman & L. A. Baltina Jr.

  2. Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, pr. Oktyabrya 71, Ufa, Bashkortostan, 450054, Russia

    L. A. Baltina, E. V. Vasil'eva & G. A. Tolstikov

Authors
  1. R. M. Kondratenko
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  2. L. A. Baltina
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  3. E. V. Vasil'eva
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  4. Kh. M. Nasyrov
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  5. R. M. Kireeva
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  6. N. Zh. Baschenko
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  7. S. M. Fridman
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  8. L. A. Baltina Jr.
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  9. G. A. Tolstikov
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Kondratenko, R.M., Baltina, L.A., Vasil'eva, E.V. et al. Synthesis and Immunomodulating Activity of New Amino Acid Derivatives of Glycyrrhizic Acid and Its Methyl Ester. Russian Journal of Bioorganic Chemistry 30, 148–153 (2004). https://doi.org/10.1023/B:RUBI.0000023100.52170.6b

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  • DOI: https://doi.org/10.1023/B:RUBI.0000023100.52170.6b

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