Abstract
Complexation of maltol (MH) with Fe3+ ions in aqueous solutions was studied. The compositions of [FeMa]2+, [FeMa2]+, and [FeMa3] complexes were determined by the method of isomolar series, and their instability constants were calculated. The values of the latter were confirmed by the method of apparent deviation from the Bouger—Lambert—Beer law. An increase in the Ma : Fe3+ ratio from 1 to 3 decreases the instability constants of the complexes. The [FeMa3] complex can be considered as a basis for the antianemic drug with a prolonged effect.
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References
A. Nobuo, K. Ryochi, and M. Toshiro, Chem. Farm. Bull., 1974, 22, 1008.
K. Takaishi, Phytochemistry, 1971, 10, 3302.
Y. Masaiti, K. Norihisa, and I. Kaichiro, Yakugaku Zasshi, 1968, 88, 390.
S. A. Mukha, I. A. Antipova, and S. A. Medvedeva, Tez. dokl. V Vseros. nauch.-prakt. konf. "Bezopasnost'-2000"[Proc. V All-Russia Scientific Practical Conf. "Safety-2000"] (Irkutsk, 2000), Irkutsk, 2000, 245 (in Russian).
H. Morita, S. Shimomura, and S. Kawaguchi, Bull. Chem. Soc. Jpn, 1978, 51, 3213.
C. Gerard, Bull. Soc. Chim. Fr., 1979, 1, 451.
M. Finnegan, T. G. Lutz, W. O. Nelson, A. Smith, and C. Orvig, Inorg. Chem., 1987, 26, 2171.
S. A. Mukha, I. A. Antipova, and S. A. Medvedeva, Tez. dokl. Mezhdunar. nauch.-prakt. konf. "Chelovek. Sreda. Vselennaya"[Proc. Intern. Scientific Practical Conf. "Human Being. Environment. Universe"] (Irkutsk, 2001), Irkutsk, 2001, 115 (in Russian).
M. T. Achmet, C. S. Frampton, and J. Silver, J. Chem. Soc., Dalton Trans., 1988, 1159.
A. Stefanovic, J. Havel, and L. Sommer, Coll. Czech. Chem. Commun., 1968, 33, 4198.
S. A. Mukha, Tez. dokl. XIII Zimnei mezhdunar. molodezhn. nauch. shkoly "Perspektivnye napravleniya fiziko-khimicheskoi biologii i biotekhnologii"[Proc. XIII Winter Intern. Youth Scientific School "Promising Directions of Physicochemical Biology and Biotechnology"] (Moscow, 2001), Moscow, 2001, 81 (in Russian).
I. V. Babenkova, Yu. O. Teselkin, S. A. Medvedeva, N. A. Tyukavkina, Yu. A. Kolesnik, L. B. Rebrov, V. A. Bykov, S. A. Mukha, and I. A. Antipova, Voprosy biologicheskoi meditsinskoi i farmatsevticheskoi khimii[Problems of Biologi-cal Medical and Pharmaceutical Chemistry], 2001, 4, 22 (in Russian).
S. A. Medvedeva, Ph. D. (Chem.) Thesis, Institute of Or-ganic Chemistry, Siberian Branch, Russian Academy of Sci-ences, Irkutsk, 1973, 138 pp. (in Russian).
RF Pat. 2171805, 2001; RZhKhim.[Abstract J. Chem.], 2002, 02.02-190.203P (in Russian).
A. K. Babko, Fiziko-khimicheskii analiz kompleksnykh soedinenii v rastvorakh[Physicochemical Analysis of Com-plexes in Solutions],Izd. Akad. Nauk UkrSSR, Kiev, 1955, 104 (in Russian).
М. I. Bulatov and I. P. Kalinkin, Prakticheskoe rukovodstvo po fotometricheskim metodam analiza[Practical Guide on Pho-tometric Methods of Analysis], Khimiya, Leningrad, 1986, 280 (in Russian).
V. A. Chernyshev and M. E. Shishniashvili, in Khelaty metallov prirodnykh soedinenii i ikh primenenie[Metal Chelates of Natural Compounds and Their Application], Metsniereba, Tbilisi, 1974, 34 (in Russian).
A. J. Gordon and R. A. Ford, The Chemist's Companion, a Handbook of Practical Data, Techniques and Referens, J. Wiley and Sons, New York-London, 1972.
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Antipova, I.A., Mukha, S.A. & Medvedeva, S.A. Determination of composition and instability constants of maltol complexes with iron(iii) ions. Russian Chemical Bulletin 53, 780–784 (2004). https://doi.org/10.1023/B:RUCB.0000037841.67079.2b
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DOI: https://doi.org/10.1023/B:RUCB.0000037841.67079.2b