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Unresolved Issues in Osteoporosis in Men

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References

  1. Kalache A. aging worldwide. In: Ebrahim S, Kalache A, eds, Epidemiology of Old Age. London: BMJ Publishing Group, 1996;22-31.

    Google Scholar 

  2. Cooper C, Campion G, Melton LJ. Hip fractures in the elderly: A world-wide projection. Osteoporosis Int 1992;2:285-289.

    Google Scholar 

  3. Kanis JA and Pitt FA Epidemiology of osteoporosis. Bone 1992;13:S7-S15.

    Google Scholar 

  4. Kannus P, Parkkari J Sievanen, Heinonen A, Vuori I, Jarvinen M. Epidemiology of hip fractures. Bone 1996;18:57S-61S.

    Google Scholar 

  5. Melton LJ III, Atkinson EJ, Madhok R. Downturn in hip fracture incidence. Public Health Rep 1996;111:146-150.

    Google Scholar 

  6. Elffors I, Allander E, Kanis JA, Gullberg B, Johnell O, Dequeker J, Dilsen G, Gennari C, Lopes Vaz AA, Lyritis G. The variable incidence of hip fracture in southern Europe: the MEDOS study. Osteoporosis Int 1994;4:253-263.

    Google Scholar 

  7. Melton LJ III, Therneau TM, Larson DR. Long-term trends in hip fracture prevalence: the influence of hip fracture incidence and survival. Osteoporosis Int 1998;8:68-74.

    Google Scholar 

  8. Bacon WE, Maggi S, Looker A, Harris T, Nair CR, Giaconi J, Honkanen R, Ho SC, Peffers KA, Torring O, Gass R, Gonzalez N. International comparison of hip fracture rates in 1988–89. Osteoporosis Int 1996;6:69-75.

    Google Scholar 

  9. Maggi S, Kelsey JL, Litvak J, Heyse SP. Incidence of hip fractures in the elderly: A cross-national analysis. Osteoporosis Int 1991;1:232-241.

    Google Scholar 

  10. Jones G, Nguyen T, Sambrook PN, Kelly PJ, Gilbert C, Eisman JA. Symptomatic fracture incidence in elderly men and women: The Dubbo Osteoporosis Epidemiology Study (DOES). Osteoporosis Int 1994;4:277-282.

    Google Scholar 

  11. O'Neill TW, Felsenberg D, Varlow J, Cooper C, Kanis JA, Silman AJ. The prevalence of vertebral deformity in European men and women: The European vertebral osteoporosis study. J Bone Miner Res 1996;11:1010-1018.

    Google Scholar 

  12. Tsai K-S, Twu S-J, Chieng P-U, Yang R-S, Lee T-K. Prevalence of vertebral fractures in Chinese men and women in urban Taiwanese communities. Calcif Tissue Int 1996;59:249-253.

    Google Scholar 

  13. Burger H, van Daele PLA, Grashuis K, Mogman A, Grobbee DE, Schutte HE, Birkenhager JC, Pols HA. Vertebral deformities and functional impairment in men and women. J Bone Miner Res 1997;12:152-157.

    Google Scholar 

  14. Davies KM, Stegman MR, Heaney RP, Recker RR. Prevalence and severity of vertebral fracture: The Saunders County Bone Quality Study. Osteoporosis Int 1996;2:160-165.

    Google Scholar 

  15. Ross PD, Lombardi A, Freedholm D. The assessment of bone mass in men. In: Orwell E, ed. Osteoporosis in Men. The Effect of Gender on Skeletal Health. San Diego, CA: Academic Press, 1999; Chap. 24, 505-525.

    Google Scholar 

  16. Poór G, Atkinson EJ, O'Fallon WM, Melton LJ III. Determinants of reduced survival following hip fractures in men. Clin Orthop Related Research 1995;319:260-265.

    Google Scholar 

  17. Diamond TH, Thornley SW, Sekel R, Smerdely P. Hip fracture in elderly men: Prognostic factors and outcomes. Med J Aust 1997;167:412-415.

    Google Scholar 

  18. Lu-Yao GL, Baron JA, Barrett JA, Fisher ES. Treatment and survival among elderly Americans with hip fractures: A population-based study. Am J Public Health 1994;84:1287-1291.

    Google Scholar 

  19. Matthis C, Weber U, O'Neill TW, Raspe H. Health impact associated with vertebral deformities: results from the European Vertebral Osteoporosis Study (EVOS). Osteoporosis Int 1998;8:364-372.

    Google Scholar 

  20. Lau EMC, Woo J, Chan H, Chan MKF, Griffith J, Chan YH, Leung PC. The health consequences of vertebral deformity in elderly Chinese men and women. Calcif Tissue Int 1998;631-4.

  21. Ray NF, Chan JK, Thamer M, Melton LJ III. Medical expenditures for the treatment of osteoporotic fractures in the United States in 1995: Reports from the national osteoporosis foundation. J Bone Miner Res 1997;12:24-35.

    Google Scholar 

  22. Randall A, Sambrook P, Nguyen T, Lapsley H, Jones G, Kelly PJ, Eisman JA. Direct clinical and welfare costs of osteoporotic fractures in elderly men and women. Osteoporosis Int 1995;5:427-432.

    Google Scholar 

  23. Seeman E. The dilemma of osteoporosis in men. Am J Med 1995;98(Suppl 1A):75S-87S.

    Google Scholar 

  24. Rupich RC, Specker BL, Lieuw-A-Fa M, Ho M. Gender and race differences in bone mass during infancy. Calcif Tissue Int 1996;58:395-397.

    Google Scholar 

  25. Gilsanz V, Boechat MI, Roe TF, Loro ML, Sayre JW, Goodman WG. Gender differences in vertebral body sizes in children and adolescents. Radiology 1994;190:673-677.

    Google Scholar 

  26. Gilsanz V, Skaggs DI, Kevanikaya A, Sayre J, Loro ML, Kaufman F, Korenman SG. Differential effects of race on the axial and appendicular skeleton of children. J Clin Endocrinol Metab 1998;83(5):1420-1427.

    Google Scholar 

  27. Gilsanz V, Boechat MI, Gilsanz R, Loro ML, Roe TF, Goodman WG. Gender differences in vertebral size in adults: Biomechanical implications. Radiology 1994b;190:678-694.

    Google Scholar 

  28. Han Z-H, Palnitkar S, Rao DS, Nelso D, Parfitt AM. Effect of ethnicity and age or menopause on the structure and geometry of iliac bone. J Bone Mine Res 1996;11:1967-1975.

    Google Scholar 

  29. Parfitt, AM. Perspective: A structural approach to renal bone disease. J Bone Miner Res 1998;13,8:1213.

    Google Scholar 

  30. Preece MA. The development of skeletal sex differences at adolescence. In: Russo P, Gass G, eds. Human adaptation. Sydney: Department of Biological Sciences, Cumberland College of Health Sciences, 1982;1-13.

    Google Scholar 

  31. Preece MA, Pan H, Ratcliffe SG. Auxological aspects of male and female puberty. Acta Paediatr 1992;383:11-13.

    Google Scholar 

  32. Garn SM. In: The Earlier Gain and Later Loss of Cortical Bone. Springfield, Illinois: C.C. Thomas Publishers, 1970.

    Google Scholar 

  33. Garn SM, Nagy JM, Sandusky ST. Differential sexual dimorphism in bone diameters of subjects of European and African ancestry. Am J Phys Anthrop 1972;37:127-130.

    Google Scholar 

  34. Bertelloni S, Baroncelli GI, Ferdeghini M, Perri G, Saggese G. Normal volumetric bone mineral density and bone turnover in young men with histories of constitutional delay of puberty. J Clin Endocrinol Metab 1998;83:4280-4283.

    Google Scholar 

  35. Bass S, Delmas PD, Pearce G, Hendricke E, Tabensky A, Seeman E. The differing tempo of growth in bone size, mass and density in girls is region-specific. J Clin Invest 1999;104:795-804.

    Google Scholar 

  36. Lu PW, Cowell CT, Lloyd-Jones SA, Brody JN, Howman-Giles R. Volumetric bone mineral density in normal subjects aged 5–27 years. J Clin Endocrinol Metab 1996;81:1586-1590.

    Google Scholar 

  37. Zamberlan N, Radetti G, Paganini C, Gatti D, Rossini M, Braga V. Evaluation of cortical thickness and bone density by roentgen microdensitometry in growing males and females. Eur J Pediatr 1996;155:377-382.

    Google Scholar 

  38. Kalender WA, Felsenberg D, Louis O, Lopez P, Klotz E, Osteaux M, Fraga J. Reference values for trabecular and cortical vertebral bone density in single and dual-energy quantitative computed tomography. Europ J Radiol 1989;9:75-80.

    Google Scholar 

  39. Aaron JE, Makins NB, Sagreiy K. The microanatomy of trabecular bone loss in normal aging men and women. Clin Orth RR 1987;215:260-271.

    Google Scholar 

  40. Kuiper JW, van Kuijk C, Grashuis JL, Ederveen AGH, Schotte HE. Accuracy and the influence of marrow fat on quantitative CT and dual-energy X-ray absorptiometry measurements of the femoral neck in vitro. Osteoporosis Int 1996;6:25-30.

    Google Scholar 

  41. Ruff CB, Hayes WC. Sex differences in age-related remodeling of the femur and tibia. J Orthop Res 1988;6:886-896.

    Google Scholar 

  42. Jones G, Nguyen T, Sambrook P, Kelly PJ, Eisman JA. Progessive loss of bone in the femoral neck in elderly people: Longitudinal findings from the Dubbo osteoporosis epidemiology study. Br Med J 1994;309:691-695.

    Google Scholar 

  43. Hannan MT, Felson DT, Kiel DP, Anderson JJ. Bone mineral density in elderly elderly men and women: Results from the Framingham osteoporosis study. J Bone Miner Res 1992;7:547-553.

    Google Scholar 

  44. Laval-Jeantet A-M, Bergot C, Carroll R, Garcia-Schaefer F. Cortical bone senescence and mineral bone density of the humerus. Calcif Tissue Int 1983;35:268-272.

    Google Scholar 

  45. Vega E, Ghiringhelli G, Mautalen C, Valzacchi GR, Scaglia H, Zylberstein C. Bone mineral density and bone size in men with primary osteoporosis and vertebral fractures. Calcif Tissue Int 1998;62:465-469.

    Google Scholar 

  46. Seeman E. Unpublished data.

  47. Cohen-Solal ME, Baudoin C, Omouri M, Kuntz D, de Vernejoul MC. Bone mass in middle-aged osteoporotic men and their relatives: Familial effect. J Bone Miner Res 1998;13:1909-1914.

    Google Scholar 

  48. Legrand E, Chappard D, Pascaretti C, Duquenne M, Krebs S, Rohmer V, Basle M-F, Audran M. Trabecular bone microarchitecture, bone mineral density and vertebral fractures in male osteoporosis. J Bone Miner Res 2000;15:13-19.

    Google Scholar 

  49. Marie PJ, de Vernejoul MC, Connes D, Hott M. Decreased DNA synthesis by cultured osteoblastic cells in eugonadal osteoporotic men with defective bone formation. J Clin Invest 1991;88:1167-1172.

    Google Scholar 

  50. Bergman RJ, Gazit D, Kahn AJ, Gruber H, McDougall S, Hahn TJ. Age-related changes in osteogenic stem cells in mice. J Bone Miner Res 1996;11:568-577.

    Google Scholar 

  51. Jilka RL, Weinstein RS, Takahashi K, Parfitt AM, Manolagas SC. Linkage of decreased bone mass with impaired osteoblastogenesis in a murine model of accelerated senescence. J Clin Invest 1996;97:1732-1740.

    Google Scholar 

  52. Kajkenova O, Lecka-Czernik B, Gubrij I, Hauser SP, Takahashi K, Parfitt AM, Jilka RL, Manolagas SC, Lipschitz DA. Increased adipogenesis and myelopoiesis in the bone marrow of SAMP6, a murine model of defective osteoblastogenesis and low turnover osteopenia. J Bone Miner Res 1997;12:1772-1779.

    Google Scholar 

  53. Weinstein RS, Jilka R, Parfitt AM, Manolagas SC. The effects of androgen deficiency on murine bone remodeling and bone mineral density are mediated via cells of the osteoblastic lineage. Endocrinology 1997;138:4013-4021.

    Google Scholar 

  54. Sone T, Miyake M, Takeda N, Fukunaga M. Urinary excretion of type I collagen crosslinked N-telopeptides in healthy Japanese adults: Age-and sex-related changes and reference limits. Bone 1995;17:335-339.

    Google Scholar 

  55. Wishart JM, Need AG, Horowitz M, Morris HA, Nordin BEC. Effect of age on bone density and bone turnover in men. Clin Endocrinol 1995;42:141-146.

    Google Scholar 

  56. Orwoll ES, Bell NH, Nanes MS, Flessland KA, Pettinger MB, Mallinak NJS, Cain D. Collagen N-telopeptide excretion in men: The effects of age and intrasubject variability. J Clin Endocrinol Metab 1998;83:3930-3935.

    Google Scholar 

  57. Resch H, Pietschmann P, Woloszczuk W, Krexner E, Bernecker P, Willvonseder R. Bone mass and biochemical parameters of bone metabolism in men with spinal osteoporosis. Euro J Clin Invest 1992;22:542-545.

    Google Scholar 

  58. Sharp CA, Worsfold M, Rowlands PR, Davie MWJ. Accurate prediction of spinal osteoporosis in men using a biochemical measure of collagen balance. Bone and tooth society summer meeting, July 22–23, 1993. Bone 1994;15:243. Abstract P57.

    Google Scholar 

  59. Need AG, Morris HA, Horowitz M, Scopacasa F, Nordin BEC. Intestinal calcium absorption in men with spinal osteoporosis. Clin Endocrinol 1998;48:163-168.

    Google Scholar 

  60. Agnusdei D, Civitelli R, Camporeale A, Parisi G, Gennari L, Nardi P, Gennari C. Age-related decline of bone mass and intestinal calcium absorption in normal males. Calcif Tissue Int 1998;63:197-201.

    Google Scholar 

  61. Scane AC, Francis RM, Sutcliffe AM, Francis MJD, Rawlings DJ, Chapple CL. Case-control study of the pathogenesis and sequelae of symptomatic vertebral fractures in men. Osteoporosis Int 1999;9:91-97.

    Google Scholar 

  62. Gomez C. Bone mineral density in hip fracture. The Spanish multi-center study. Abstracts of the Spanish society for bone and mineral research. Cordoba, Spain, October 20–23, 1993. Calcif Tissue Int 1994;55:440.

    Google Scholar 

  63. Smith EP, Boyd J, Frank GR, Takahashi H, Cohen RM, Specker B, Williams TC, Lubahn DB, Korach KS. Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med 1994;331:1056-1061.

    Google Scholar 

  64. Bilezikian JP, Morishima A, Bell J, Grumbach MM. Increased bone mass as a result of estrogen therapy in a man with aromatase deficiency. New Eng J Med 1998;339:599-603.

    Google Scholar 

  65. Hofhauer LC and Khosla S. Androgen effects on bone metabolism: Recent progress and controversies. European J Endocrinol 1999;140:271-286.

    Google Scholar 

  66. Somjen D, Mor Z, Kaye AM. Age dependence and modulation by gonadectomy of the sex-specific response of rat diaphyseal bone to gonadal steroids. Endocrinology 1994;134:809-814.

    Google Scholar 

  67. Schwartz Z, Nasatzky E, Ornoy A, Brooks BP, Soskolne WA, Boyan BD. Gender-specific, maturation-dependent effects of testosterone on chondrocytes in culture. Endocrinology 1994;134:1640-1647.

    Google Scholar 

  68. Kasperk CH, Wakley GK, Hierl T, Ziegler R. Gonadal and adrenal androgens are potent regulators of human bone cell metabolism in vitro. J Bone Miner Res 1997;12:464-471.

    Google Scholar 

  69. Gunness M, Orwoll E. Early induction of alterations in cancellous and cortical bone histology after orchiectomy in mature rats. J Bone Miner Res 1995;10:1735-1744.

    Google Scholar 

  70. Vanderschueren D, Van Herck E, Geusens P, Suiker A, Visser W, Chung K, Bouillon R. Androgen resistance and deficiency have different effects on the growing skeleton of the rat. Calcif Tissue Int 1994;55:198-203.

    Google Scholar 

  71. Wakley GK, Evans GL, Turner RT. Short-term effects of high dose estrogen on tibiae of growing male rats. Calcif Tissue Int 1997;60:37-42.

    Google Scholar 

  72. Vanderschueren D, Van Herck E, Nijs J, Ederveen AGH, de Coster R, Bouillon R. Aromatase inhibition impairs skeletal modeling and decreases bone mineral density in growing male rats. Endocrinology 1997;138:2301-2307.

    Google Scholar 

  73. Zhang XZ, Kalu DN, Erbas B, Hopper JL, Seeman E. The effect of gonadectomy on bone size, mass and volumetric density in growing rats may be gender-, site-, and growth hormone-dependent. J Bone Miner Res 1999;14(5):802-809.

    Google Scholar 

  74. Urban RJ, Veldhuis JD, Blizzard RM, Dufau ML. Attenuated release of biologically active luteinizing hormone in healthy aging men. J Clin Invest 1988;81:1020-1029.

    Google Scholar 

  75. Haji M, Tanaka S, Nish Y, Yanase T, Takayanasi R, Hasegawa Y, Sasamoto S, Nawata H. Sertoli cell function declines earlier than Leydig cell function in aging Japanese men. Maturitas 1994;18:143-153.

    Google Scholar 

  76. Rudman D, Drinka PJ, Wilson CR, Mattson DE, Scherman F, Cuisinier MC, Schultz S. Relations of endogenous anabolic hormones and physical activity to bone mineral density and lean body mass in elderly men. Clin Endocrinol 1994;40:653-661.

    Google Scholar 

  77. Khosla S, Melton LJ III, Atkinson EJ, O'Fallon WM, Klee GG, Riggs BL. Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: A key role for bioavailable estrogen. J Clin Endocrinol Metab 1998;83:2266-2274.

    Google Scholar 

  78. Ongphiphadhanakul B, Rajatanavin R, Chanprasertyothin S, Piaseu N, Chailurkit L. Serum oestradiol and oestrogen-receptor gene polymorphism are associated with bone mineral density independently of serum testosterone in normal males. Clin Endocrinol 1998;49:803-809.

    Google Scholar 

  79. Greendale GA, Edelstein S, Barrett-Connor E. Endogenous sex steroids and bone mineral density in older women and men: The Rancho Bernardo Study. J Bone Miner Res 1997;12:1833-1843.

    Google Scholar 

  80. Slemenda CW, Longcope C, Zhou L, Hui SL, Peacock M, Johnston CC. Sex steroids and bone mass in older men. Positive associations with serum estrogens and negative associations with androgens. J Clin Invest 1997;100:1755-1759.

    Google Scholar 

  81. Seeman E, Melton LJ, O'Fallon WM and Riggs BL. Risk factors for osteoporosis in males. Am J Med 1983;75:977-982.

    Google Scholar 

  82. Stanley HL, Schmitt BP, Poses RM, Diess WP. Does hypogonadism contribute to the occurrence of a minimal trauma hip fracture in elderly men? J Am Geriatr Soc 1991;39:766-771.

    Google Scholar 

  83. Boonen S, Vanderschueren D, Cheng XG, Verbaeke G, Dequeker J, Geusens P, Broos P, Bouillon R. Age-related (type II) femoral neck osteoporosis in men: Biochemical evidence for both hypovitaminosis D-and androgen deficiency-induced bone resorption. J Bone Miner Res 1997;12:2119-2126.

    Google Scholar 

  84. Gillberg P, Johansson AG, Ljunghall S. Decreased estradiol levels and free androgen index and elevated sex hormone-binding globulin levels in male idiopathic osteoporosis. Calcif Tissue Int 1999;64:209-213.

    Google Scholar 

  85. Barrett-Connor E, Mueller JE, Von Muhlen DG, GA Laughlin, Schneider DL, Sartoris DJ. Low levels of estradiol are associated with vertebral fractures in older men, but not women: The Rancho Bernado Study. J Clin Endocrinol Metab 2000;219-223.

  86. Yeh JK, Chen M-M, Aloia JF. Ovariectomy-induced high turnover in cortical bone is dependent on pituitary hormone in rats. Bone 1996;18:443-450.

    Google Scholar 

  87. Yeh JK, Chen M-M, Aloia JF. Effects of estrogen and growth hormone on skeleton in the ovariectomized rat with hypophysectomy. Am J Physiol 1997;36:E734-E742.

    Google Scholar 

  88. Olle GP, Isaksson A, Lindahl A, Nilsson A, Isgaard J. Mechanism of the stimulatory effect of growth hormone on longitudinal bone growth. Endocrine Reviews 1987;8:426-438.

    Google Scholar 

  89. Hobbs CJ, Plymate SR, Rosen CJ, Adler RA. Testosterone administration increases insulin-like growth factor-1 levels in normal men. J Clin Endocrinol Metab 1993;77:776-779.

    Google Scholar 

  90. Morales AJ, Nolan JJ, Nelson CJ, Yen SSC. Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age. J Clin Endocrinol Metab 1994;78:1360-1367.

    Google Scholar 

  91. Weissberger AJ and Ho KKY. Activation of the somatotropic axis by testosterone in adult males: Evidence for the role of aromatization. J Clin Endocrinol Metab 1993;76:1407-1412.

    Google Scholar 

  92. Ho KY, Evans WS, Blizzard RM, Veldhuis JD, Merriam GR, Samojlik E, Furlanetto R, Rogol AD, Kaiser DL, Thorner MO. Effects of sex and age on the 24-hour profile of growth hormone secretion in man: importance of endogenous estradiol concentrations. J Clin Endocrinol Metab 1987;64:51-58.

    Google Scholar 

  93. Wright NM, Renault J, Willi S, Veldhuis D, Pandey JP, Gordon L, Key LL, Bell NH. Greater secretion of growth hormone in black than in white men: Possible factor in greater bone mineral density, a clinical research center study. J Clin Endocrinol Metab 1995;80:2291-2297.

    Google Scholar 

  94. Horton R, Pasupuletti V, Antonipillai I. Androgen induction of steroid 5 alpha reductase may be mediated via insulin-like growth factor-1. Endocrinology 1993;133:447-451.

    Google Scholar 

  95. Rosen CJ, Donahue LR, Hunter SJ. Insulin-like growth factors and bone: The osteoporosis connection. Proc Soc Exp Biol Med 1994;206:83-102.

    Google Scholar 

  96. Poehlman ET, Copeland KC. Influence of physical activity on insulin-like growth factor-1 in healthy younger and older men. J Clin Endocrinol Metab 1990;71:1468-1473.

    Google Scholar 

  97. Felsing NE, Brasel JA, Cooper DM. Effect of low and high intensity exercise on circulating growth hormone in men. J Clin Endocrinol Metab 1992;75:157-162.

    Google Scholar 

  98. Johansson AG, Forslundm A, Hambraeus L, Blum WE, Ljunghall S. Growth Hormone dependent insulin like growth factor binding protein is a major determinant of bone mineral density in healthy men. J Bone Miner Res 1994;9:915-921.

    Google Scholar 

  99. Kurland ES, Rosen CJ, Cosman F, McMahon D, Chan F, Shane E, Lindsay R, Dempster D, Bilezikian JP. Insulin-like growth factor-I in men with idiopathic osteoporosis. J Clin Endocrinol Metab 1997;82:2799-2805.

    Google Scholar 

  100. Kurland ES, Chan FKW, Rosen CJ, Bilezikian JP. Normal growth hormone secretory reserve in men with idiopathic osteoporosis and reduced circulating levels of insulin-like growth factor-I. J Clin Endocrinol Metab 1998;83:2576-2579.

    Google Scholar 

  101. Johansson AG, Eriksen EF, Lindh E, Langdahl B, Blum WF, Lindahl A, Ljunggren O, Ljunghall S. Reduced serum levels of the growth hormone-dependent insulin-like growth factor binding protein and a negative bone balance at the level of individual remodeling units in idiopathic osteoporosis in men. J Clin Endocrinol Metab 1997;82:2795-2798.

    Google Scholar 

  102. Wuster C, Blum WF, Schlemilch S, Ranke MB, Ziegler R. Decreased serum levels of insulin-like growth factors and IGF binding protein 3 in osteoporosis. J Intern Med 1993;234:249-255.

    Google Scholar 

  103. Cheng S, Suominen H, Sakari-Rantala R, Laukkanen P, Avikainen V, Heikkinen E. Calcaneal bone mineral density predicts fracture occurrence: A five-year follow-up study in elderly people. J Bone Miner Res 1997;12:1075-1082.

    Google Scholar 

  104. Lunt M, Felsenberg D, Reeve J, Benevolenskaya L, Cannata J, Dequeker J, Dodenhog C, Falch JA, Masaryk P, Pols HAP, Poor G, Reid DM, Scheidt-Nave C, Webver K, Varlow J, Kanis JA, O'Neill TW, Silman AJ. Bone density variation and its effects on risk of vertebral deformity in men and women studied in thirteen European centers: The EVOS study. J Bone Miner Res 1997;12:1883-1894.

    Google Scholar 

  105. Nyquist F, Gärdsell P, Sernbo I, Jeppsson JO, Johnell O. Assessment of sex hormones and bone mineral density in relation to occurrence of fracture in men: A prospective population-based study. Bone 1998;22:147-151.

    Google Scholar 

  106. De Laet CEDH, van Hout BA, Burger H, Hofman A, Pols HA. Bone density and risk of hip fracture in men and women: Cross setional analysis. BMJ 315:221-225.

  107. Looker AC, Orwoll ES, Johnston CC Jr, Lindsay RL, Wahner HW, Dunn WL, Calvo MS, Harris TB, Heyse SP. Prevalence of low femoral neck bone density in older US adults from NHANEA III. J Bone Miner Res 1997;12:1761-68.

    Google Scholar 

  108. Anderson FH, Francis RM, Bishop JC, Rawlings DJ. Effect of intermittent cyclical disodium etidronate therapy on bone mineral density in men with vertebral fractures. Age Ageing 1997;26:359-365.

    Google Scholar 

  109. Van Ho, Y, Seeman E. Effect of alendronate in women and men with primary or secondary osteoporosis. Osteoporosis Int 2000;9:98-1012.

    Google Scholar 

  110. Orwoll E, Ettinger M, Weiss S, Miller P, Kendler D, Graham J, Adami S, Weber K, Lorenc R, Pietschmann P. Alendraonte treatment of osteoporosis in men. Abst 1205, p S184 J Bone Miner Res 1999;14:S184. Suppl 1. 21st Annual Meeting ASBMR, St Louis, Missouri, USA.

    Google Scholar 

  111. Leifke E, Körner H-C, Link TM, Behre HM, Peters PE. Effects of testosterone replacement therapy on cortical and trabecular bone mineral density, vertebral body area and paraspinal muscle area in hypogonadal men. Eur J Endocrinol 1998;138:51-58.

    Google Scholar 

  112. Behre HM, Kliesch S, Leifke E, Link TM, Nieschlag E. Long-term effect of testosterone therapy on bone mineral density in hypogonadal men. J Clin Endocrinol Metab 1997;82:2386-2390.

    Google Scholar 

  113. Katznelson L, Finkelstein JS, Schoenfeld DA, Rosenthal DI, Anderson EJ, Klibanski A. Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism. J Clin Endocrinol Metab 1996;81:4358-4365.

    Google Scholar 

  114. Anderson FH, Francis RM, Faulkner K. Androgen supplementation in eugonadal men with osteoporosis—effects of 6 months of treatment on bone mineral density and cardiovascular risk factors. Bone 1996;18:171-177.

    Google Scholar 

  115. Bhasin S, Storer TW, Berman N, Callegari C, Clevenger B, Phillips J, Bunnell TJ, Tricker R, Shirazi A, Casaburi R. The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men. N Engl J Med 1996;335:1-7.

    Google Scholar 

  116. Dawson-Hughes B, Harris SS, Krall EA, Dallal GE. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years or older. N Engl J Med 1997;337:670-666.

    Google Scholar 

  117. Orwell WES, Oviatt SK, McClung MR, Deftos LJ, Sexton G. The rate of bone mineral loss in normal men and the effects of calcium and cholecalciferol supplementation. Ann Int Med 1990;112:29-34.

    Google Scholar 

  118. Ebeling PR, Wark JD, Yeung S, Poon C, Salehi N, Nicholson GC, Kotowicz MA. Effects of calcitriol or calcium on bone mineral density, bone turnover and fractures in men with idiopathic osteoporosis. Abstract, Australian and New Zealand Bone and Mineral Society Annual Scientific Meeting 1998; Aug 26–28.

  119. Ringe JD, Dorst A, Kipshoven C, Rovati LC, Setnikar I. Avoidance of vertebral fractures in men with idiopathic osteoporosis by a three year therapy with calcium and low-dose intermittent monofluorophosphate. Osteoporosis Int 1998;8:47-52.

    Google Scholar 

  120. Selective androgen receptor modulators (SARMS): A novel approach to androgen therapy for the new millenium. J Clin Endocrinol Metab 1999;84:3459-3462.

    Google Scholar 

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Ego, S. Unresolved Issues in Osteoporosis in Men. Rev Endocr Metab Disord 2, 45–64 (2001). https://doi.org/10.1023/A:1010054924085

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