Abstract
WHETHER amphetamine exerts its behavioural excitatory action in the brain directly or indirectly by interference or synergism with the catecholamines (noradrenaline and dopamine) is open to debate1,2. The advent of α-methyl para-tyrosine3 (α-MPT), which inhibits the in vivo synthesis of 3,4-dihydroxyphenylalanine (DOPA)—the physiological precursor of the catecholamines—offers a new way of investigating this problem.
Similar content being viewed by others
Article PDF
References
Rech, R., J. Pharmacol. Exp. Therap., 146, 369 (1964).
Quinton, R., and Halliwell, G., Nature, 200, 178 (1963).
Spector, S., Sjoerdsma, A., and Udenfriend, S., J. Pharmacol. Exp. Therap., 147, 86 (1965).
Randrup, A., Munkvad, I., and Udsen, P., Acta Pharmacol. Toxicol., 20, 145 (1963).
Randrup, A., and Munkvad, I., Psychopharmacologia, 7, 416 (1965).
Randrup, A., and Munkvad, I. (in preparation).
Leslie, G., and Maxwell, D., Brit. J. Pharmacol., 22, 301 (1964).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
RANDRUP, A., MUNKVAD, I. Role of Catecholamines in the Amphetamine Excitatory Response. Nature 211, 540 (1966). https://doi.org/10.1038/211540a0
Issue Date:
DOI: https://doi.org/10.1038/211540a0
This article is cited by
-
Neurochemical and behavioural characterisation of alkoxyamphetamine derivatives in rats
Neurotoxicity Research (2006)
-
Behavioural assessment of pinealectomy and foetal pineal gland transplantation in rats: Part II
Acta Neurochirurgica (1994)
-
The contribution of the different binding sites of the N-methyl-D-aspartate (NMDA) receptor to the expression of behavior
Journal of Neural Transmission (1992)
-
Amphetamine, apomorphine and investigatory behavior in the rat: Analysis of the structure and pattern of responses
Psychopharmacology (1986)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.