Abstract
WE have described two molecular species of interferon induced by statolon1. Both are proteins and one (produced in tissue culture) has a molecular weight of 30,000 with an electrophoretic mobility similar to that of virus induced interferon, whereas the other (produced in vivo) has a molecular weight of 85,000 and an electrophoretic mobility which differs significantly from that of virus induced interferon. In the present communication we report that the lighter of these species can also be produced in vivo by statolon. W. Van Rossum and P. de Somer have found the spleen to be a very active interferon producing organ (personal communication). We have-investigated extracts of spleens from mice injected with statolon and find that, whereas the heavier interferon species is produced in the serum, the lighter variety is produced in the spleen of such mice.
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References
Merigan, T. C., and Kleinschmidt, W. J., Nature, 208, 667 (1965).
Merigan, T. C., Winget, C. A., and Dixon, C. B., J. Mol. Biol., 13, 679 (1965).
Hallum, J. V., Stinebring, V. R., and Youngner, J. S., Virology, 27, 429 (1965).
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MERIGAN, T., KLEINSCHMIDT, W. A Second Molecular Species of Mouse Interferon in Mice injected with Statolon. Nature 212, 1383–1384 (1966). https://doi.org/10.1038/2121383a0
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DOI: https://doi.org/10.1038/2121383a0
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