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Tertiary Structure of Ribonuclease

Abstract

A model is proposed of the polypeptide chain in bovine pancreatic ribonuclease based on a 2 Å electron density map involving 7,294 reflexions and data from seven heavy atom derivatives. The molecule seems to be roughly kidney shaped with dimensions of about 38 × 28 × 22 Å with a deep depression in the middle of one side. The model disagrees with that based on a 5.5 Å map suggested by Dr. C. H. Carlisle et al. (Nature, 213, 557; 1967).

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KARTHA, G., BELLO, J. & HARKER, D. Tertiary Structure of Ribonuclease. Nature 213, 862–865 (1967). https://doi.org/10.1038/213862a0

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