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Effect of Methionine Sulphoximine on Memory Transfer

Nature volume 217, pages 680–681 (1968)Cite this article

Abstract

METHIONINE sulphoximine influences the metabolism in the central nervous system in a number of different ways1. It affects the glutamine formation in the brain2, decreases the incorporation of phosphorus-32 in cytoplasmic ribonucleic acid3 and decreases the incorporation of methionine labelled with sulphur-35 into the brain proteins4. Methionine sulphoximine is an epileptogenic agent5 and in subconvulsive doses it blocks alimentary conditioned reflexes6. Injection of this compound causes pathological changes in the synapses where considerable quantities of the drug are found7.

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References

  1. Koloušek, J., First Intern. Meeting Intern. Soc. Neurochem., Strasbourg, Abstracts, 120 (1967).

  2. Koloušek, J., and Jiráček, V., J. Neurochem., 4, 178 (1959).

    Article  Google Scholar 

  3. Žák, R., Klicpera, M., and Koloušek, J., in Proc. Conference on Use of Radioactive Isotopes in Biology and Medicine, Prague (1958).

    Google Scholar 

  4. Koloušek, J., and Lodin, Z., Physiologia Bohemoslovenica, 8, 129 (1959).

    Google Scholar 

  5. Misani, F., and Reiner, L., Arch. Biochem., 27, 234 (1950).

    CAS  PubMed  Google Scholar 

  6. Lodin, Z., and Koloušek, J., Physiologia Bohemoslovenica, Suppl., 5, 43 (1956).

    CAS  PubMed  Google Scholar 

  7. Robertis, E., De Sellinger, O. Z., De Lores, R., Arnaiz, G., Alberici, M., and Zieher, L. M., J. Neurochem., 14, 81 (1967).

    Article  Google Scholar 

  8. Kendall, M. G., Rank Correlation Methods (Griffin and Co., London, 1955).

    MATH  Google Scholar 

  9. Hydén, H., and Egyhari, E., Proc. US Nat. Acad. Sci., 52, 1030 (1964).

    Article  ADS  Google Scholar 

  10. Rosenblatt, F., Farrow, J. T., and Herblin, W. F., Nature, 209, 46 (1966).

    Article  ADS  CAS  Google Scholar 

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Authors and Affiliations

  1. Ghana Medical School, Accra, Ghana

    STANISLAV REINIŠ

  2. Institute of Biophysics, Charles University, Prague, Czechoslovakia

    JAROSLAV KOLOUŠEK

Authors
  1. STANISLAV REINIŠ
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  2. JAROSLAV KOLOUŠEK
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REINIŠ, S., KOLOUŠEK, J. Effect of Methionine Sulphoximine on Memory Transfer. Nature 217, 680–681 (1968). https://doi.org/10.1038/217680a0

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