Abstract
LABORATORY mice of defined genetic qualities and, more recently, so-called germ-free (gnotobiotic, axenic) mice have become available to investigators. Electron microscopy has revealed, however, that the so-called germ-free mice (AKR, Balb/c, C3Hf, CFW, ICR and Swiss-Webster strains) were not virus-free1–3. Virus-like particles were observed in the thymic tissues of prenatal, neonatal and mature “germ-free” mice3. Moreover, significant numbers of mice from each strain developed lymphatic leukaemia after whole-body exposure to X-rays, which served to identify some of the virus particles in their tissues4. The development of a virus-free mouse strain would be very useful for determining the exclusive causal role of virus in leukaemogenesis. We have therefore examined additional conventional mouse strains for leukaemia virus by electron microscopy and some also for host-response to the leukaemogenic action of whole-body irradiation.
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KAJIMA, M., POLLARD, M. Wide Distribution of Leukaemia Virus in Strains of Laboratory Mice. Nature 218, 188–189 (1968). https://doi.org/10.1038/218188a0
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DOI: https://doi.org/10.1038/218188a0
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