Abstract
STUDIES of the final stages of glycolysis and the initial stages of the citric acid cycle in progressive muscular dystrophy have used indirect methods, such as the determination of serum levels of corresponding metabolites. In this context two facts are interesting: the increase of pyruvicaemia1–4 simultaneous with the decrease of citric acid3,4, and the normality of lactate, α-cetoglutarate and oxalacetate serum values3,4. Only the decrease in the concentration of citric acid would be exclusively specific to progressive muscular dystrophy3,4.
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Beckmann, R., and Billich, Ch., Med. Welt, 19, 1085 (1962).
Luzzatto, A., and Ramelli, E., Cervello, 6, 377 (1959).
Niebroj-Dobosz, I., and Hausmanowa-Petrusewicz, I., Acta Med. Pol., 2, 117 (1965).
Niebroj-Dobosz, I., and Hausmanowa-Petrusewicz, I., Acta Med. Pol., 2, 125 (1965).
Novelli, D., Methods for Biochemical Analysis (edit. by Glick, D.), 2, 189 (Interscience, New York, 1955).
Radu, H., Gödri, I., Blücher, G., Migea, S., and Bordeianu, L., Progressive Muskeldystrophie. Myotonie. Myasthenie. (edit. by Kuhn, E.), 139 (Springer, Berlin–Heidelberg–New York, 1966).
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RADU, H., KAPUSI, A. & STENZEL, K. Defect of Coenzyme-A Activity in Progressive Muscular Dystrophy. Nature 219, 505 (1968). https://doi.org/10.1038/219505a0
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DOI: https://doi.org/10.1038/219505a0
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