Abstract
SEVERAL observations1,2 suggest that the metabolism of indoles, particularly 5-hydroxytryptamine (serotonin), is disturbed in affective illness. The introduction of methysergide as a potent and specific antiserotonin agent suggests possible applications in affective illness.
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References
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Richter, D., in Amines and Schizophrenia (edit. by Himwich, H. E., Kety, S., and Smythies, J. R.), 167 (Pergamon Press, London, 1967).
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Dewhurst, W. G., in Studies in Psychiatry (edit. by Shepherd, M., and Davies, D. L.), 289 (Oxford University Press, London, 1968).
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HAŠKOVEC, L., SOUČEK, K. Trial of Methysergide in Mania. Nature 219, 507–508 (1968). https://doi.org/10.1038/219507a0
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DOI: https://doi.org/10.1038/219507a0
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