Abstract
MONOAMINE oxidase (MAO) inhibitors were the first clinically used antidepressant drugs. Several tricyclic compounds of iminodibenzyl or cycloheptadiene structure which do not inhibit MAO are also effective antidepressant drugs (refs. 1–3 and unpublished work of J. M. Davis, G. L. Klerman and J. J. Schildkraut), and seem to act by inhibiting the re-uptake inactivation of noradrenaline4–7 and potentiating its effects in the brain.
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HENDLEY, E., SNYDER, S. Relationship between the Action of Monoamine Oxidase Inhibitors on the Noradrenaline Uptake System and their Antidepressant Efficacy. Nature 220, 1330–1331 (1968). https://doi.org/10.1038/2201330a0
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DOI: https://doi.org/10.1038/2201330a0
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