Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Factor Stimulating Transcription by RNA Polymerase

Abstract

A protein component usually associated with RNA polymerase can be separated from the enzyme by chromatography on phosphocellulose. The polymerase is unable to transcribe T4 DNA unless this factor is added back.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Chamberlin, M., and Berg, P., Proc. US Nat. Acad. Sci, 48, 81 (1962).

    Article  ADS  CAS  Google Scholar 

  2. Furth, J. J., Hurwitz, J., and Anders, M., J. Biol Chem., 237, 2611 (1962).

    CAS  PubMed  Google Scholar 

  3. Stevens, A., and Henry, J., J. Biol. Chem., 239, 196 (1964).

    CAS  PubMed  Google Scholar 

  4. Fuchs, E., Zillig, W., Hofschneider, P. H., and Preuss, D., J. Mol. Biol., 10, 546 (1964).

    Article  CAS  Google Scholar 

  5. Richardson, J. P., Proc. US Nat. Acad. Sci., 55, 1616 (1966).

    Article  ADS  CAS  Google Scholar 

  6. Babinet, C., Biochem. Biophys. Res. Commun., 26, 639 (1967).

    Article  CAS  Google Scholar 

  7. Hayashi, M., Hayashi, M. N., and Spiegelman, S., Proc. US Nat. Acad. Sci., 51, 351 (1964).

    Article  ADS  CAS  Google Scholar 

  8. Geiduschek, E. P., Tocchini-Valentini, G. P., and Sarnat, M., Proc. US Nat. Acad. Sci., 52, 486 (1964).

    Article  ADS  CAS  Google Scholar 

  9. Green, M., Proc. US Nat. Acad. Sci., 52, 1388 (1964).

    Article  ADS  CAS  Google Scholar 

  10. Luria, S. E., Biochem. Biophys. Res. Commun., 18, 735 (1965).

    Article  CAS  Google Scholar 

  11. Hayashi, M., Hayashi, M. N., and Spiegelman, S., Proc. US Nat. Acad. Sci., 50, 664 (1963).

    Article  ADS  CAS  Google Scholar 

  12. Tocchini-Valentini, G. P., Stodolsky, M., Sarnat, M., Aurisicchio, A., Graziosi, F., Weiss, S. B., and Geiduschek, E. P., Proc. US Nat. Acad. Sci., 50, 935 (1963).

    Article  ADS  CAS  Google Scholar 

  13. Marmur, J., and Greenspan, C. M., Science, 142, 387 (1963).

    Article  ADS  CAS  Google Scholar 

  14. Khesin, R. B., Shemyakin, M. F., Gorlenko, Zh. M., Bogdanova, S. L., and Afanaseva, T. P., Biokhimiya, 27, 1092 (1962).

    CAS  Google Scholar 

  15. Geiduschek, E. P., Snyder, L., Colvill, A. J. E., and Sarnat, M., J. Mol. Biol., 19, 541 (1966).

    Article  CAS  Google Scholar 

  16. Naono, S., and Gros, F., Cold Spring Harbor Symp. Quant. Biol., 31, 363 (1966).

    Article  CAS  Google Scholar 

  17. Cohen, S. N., Maitra, U., and Hurwitz, J., J. Mol. Biol., 26, 19 (1967).

    Article  CAS  Google Scholar 

  18. Crawford, L. V., Crawford, E. M., Richardson, J. P., and Slayter, H. S., J. Mol. Biol., 14, 593 (1965).

    Article  CAS  Google Scholar 

  19. Richardson, J. P., J. Mol. Biol., 21, 83 (1966).

    Article  CAS  Google Scholar 

  20. Jones, O. W., and Berg, P., J. Mol. Biol., 22, 199 (1966).

    Article  CAS  Google Scholar 

  21. Pettijohn, D., and Kamiya, T., J. Mol. Biol, 29, 275 (1967).

    Article  CAS  Google Scholar 

  22. Sentenac, A., Ruet, A., and Fromageot, P., Europ. J. Biochem., 5, 385 (1968).

    Article  CAS  Google Scholar 

  23. Priess, H., and Zilling, W., Biochim. Biophys. Acta, 140, 540 (1967).

    Article  CAS  Google Scholar 

  24. Stevens, A., Emery, jun., A. J., and Sternberger, N., Biochem. Biophys. Res. Commun., 24, 929 (1966).

    Article  CAS  Google Scholar 

  25. Smith, D. A., Martinez, A. M., Ratliff, R. L., Williams, D. L., and Hayes, F. N., Biochemistry, 6, 3057 (1967).

    Article  CAS  Google Scholar 

  26. Zillig, W., Fuchs, E., and Millette, R., in Proc. Nucleic Acid Res. (edit. by Cantoni, G. L., and Davies, D. R.), 326 (Academic Press, New York, 1966).

    Google Scholar 

  27. Burgess, R. R., Fed. Proc., 27, 295 (1968).

    Google Scholar 

  28. Alberts, B. M., Amodio, F. J., Jenkins, M., Gutman, E. D., and Ferris, F. L., Cold Spring Harbor Symp. Quant. Biol., 33 (in the press).

  29. Shapiro, A., Vinuela, E., and Maizel, J. V., Biochem. Biophys. Res. Commun., 28, 815 (1967).

    Article  CAS  Google Scholar 

  30. Walter, G., Seifert, W., and Zillig, W., Biochem. Biophys. Res. Commun., 30, 240 (1968).

    Article  CAS  Google Scholar 

  31. Maitra, U., and Hurwitz, J., J. Biol. Chem., 242, 4897 (1967).

    CAS  PubMed  Google Scholar 

  32. Tocchini–Valentini, G. P., Marino, P., and Colvill, A. J., Nature, 220, 275 (1968).

    Article  ADS  Google Scholar 

  33. Maaløe, O., and Kjeldgaard, N. O., Control of Macromolecular Synthesis (Benjamin, New York, 1966).

    Google Scholar 

  34. Davis, B. J., Ann. NY Acad. Sci., 121, 406 (1964).

    ADS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

BURGESS, R., TRAVERS, A., DUNN, J. et al. Factor Stimulating Transcription by RNA Polymerase. Nature 221, 43–46 (1969). https://doi.org/10.1038/221043a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/221043a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing