Abstract
AN abnormal haemoglobin with a substitution involving a proline residue might be expected to be either unstable or functionally abnormal because of the inevitable conformational changes which occur. This has been borne out in the cases of haemoglobins Genova, Dhofar, Bibba and Santa Ana, all of which are unstable and associated with Heinz body anaemia1. Replacements involving proline residues do not, however, invariably result in these changes. Thus Hb-Chiapas2,3 is not unstable and its presence does not lead to clinical or haematological symptoms. We have recently observed two new haemoglobin variants of this type which are also not associated with marked molecular instability.
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CLEGG, J., WEATHERALL, D., BOON, W. et al. Two New Haemoglobin Variants involving Proline Substitutions. Nature 222, 379–380 (1969). https://doi.org/10.1038/222379a0
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DOI: https://doi.org/10.1038/222379a0
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