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Nucleotide Sequence from the Coat Protein Cistron of R17 Bacteriophage RNA

Abstract

The sequence of fifty-seven nucleotides in the coat protein cistron of phage R17 RNA directly confirms the genetic code, shows that the code used by the phage is degenerate and suggests that highly ordered base-paired structures exist in this RNA. Such base-paired loops may be involved in regulation of cistron expression and packing of the RNA in the phage particle.

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References

  1. Gesteland, R. F., and Boedtker, H., J. Mol. Biol., 8, 496 (1964).

    Article  CAS  Google Scholar 

  2. Dahlberg, J. E., Nature, 220, 548 (1968).

    Article  ADS  CAS  Google Scholar 

  3. De Wachter, R., and Fiers, W., J. Mol. Biol., 30, 507 (1967).

    Article  CAS  Google Scholar 

  4. Weith, H. L., and Gilham, P. T., J. Amer. Chem. Soc., 89, 5473 (1967).

    Article  CAS  Google Scholar 

  5. Roblin, R., J. Mol. Biol., 31, 51 (1968).

    Article  CAS  Google Scholar 

  6. De Wachter, R., Verhassel, J-P., and Fiers, W., FEBS Lett., 1, 93 (1968).

    Article  CAS  Google Scholar 

  7. Min Jou, W., and Fiers, W., J. Mol. Biol., 40, 187 (1969).

    Article  Google Scholar 

  8. Gussin, G. N., J. Mol. Biol., 21, 435 (1966).

    Article  CAS  Google Scholar 

  9. Weber, K., Biochemistry, 6, 3144 (1967).

    Article  CAS  Google Scholar 

  10. Sanger, F., Brownlee, G. G., and Barrell, B. G., J. Mol. Biol., 13, 373 (1965).

    Article  CAS  Google Scholar 

  11. Brownlee, G. G., and Sanger, F., J. Mol. Biol., 23, 337 (1967).

    Article  CAS  Google Scholar 

  12. Brownlee, G. G., Sanger, F., and Barrell, B. G., J. Mol. Biol., 34, 379 (1968).

    Article  CAS  Google Scholar 

  13. Goodman, H. M., Abelson, J., Landy, A., Brenner, S., and Smith, J. D., Nature, 217, 1019 (1968). Dube, S. K., Marcker, K. A., Clark, B. F. C., and Cory, S., Nature, 218, 232 (1968). Cory, S., Marcker, K. A., Dube, S. K., and Clark, B. F. C., Nature, 220, 1039 (1968). Barrell, B. G., and Sanger, F., FEBS Lett., 3, 275 (1969). Yaniv, M., and Barrell, B. G., Nature, 222, 278 (1969).

    Article  ADS  CAS  Google Scholar 

  14. Brownlee, G. G., and Sanger, F., Europ. J. Biochem. (in the press).

  15. Gilham, P. T., J. Amer. Chem. Soc., 84, 687 (1962).

    Article  CAS  Google Scholar 

  16. Arima, T., Uchida, T., and Egami, F., Biochem. J., 106, 609 (1968).

    Article  CAS  Google Scholar 

  17. Gould, H. J., J. Mol. Biol., 29, 307 (1967).

    Article  CAS  Google Scholar 

  18. Peacock, A. C., and Dingman, C. W., Biochemistry, 6, 1818 (1967).

    Article  CAS  Google Scholar 

  19. Loening, U. E., Biochem. J., 102, 25 (1967).

    Article  Google Scholar 

  20. Gould, H. J., Pinder, J. C., and Matthews, H. R., Analyt. Biochem., 29, 1 (1969).

    Article  CAS  Google Scholar 

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ADAMS, J., JEPPESEN, P., SANGER, F. et al. Nucleotide Sequence from the Coat Protein Cistron of R17 Bacteriophage RNA. Nature 223, 1009–1014 (1969). https://doi.org/10.1038/2231009a0

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