Abstract
In the earliest stages of the development of mouse embryos, RNA synthesis can be blocked without inhibition of protein synthesis; but stopping protein synthesis depresses RNA synthesis.
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References
Thomson, J. L., and Biggers, J. D., Exp. Cell Res., 41, 411 (1966).
Mintz, B., J. Exp. Zool., 157, 85 (1964).
Skalko, R. G., and Morse, J. M. D., Teratology, 2, 47 (1969).
Silagi, S., Exp. Cell Res., 32, 149 (1963).
Edwards, R. G., and Gates, A. H., J. Endocrinol., 18, 292 (1959).
Brinster, R. L., Exp. Cell Res., 32, 205 (1963).
Schmidt, G., and Thannhauser, S., J. Biol. Chem., 161, 83 (1945).
Woodland, H. R., and Graham, C. F., Nature, 22l, 327 (1969).
Ellem, K. A. O., and Gwatkin, R. B. L., Develop. Biol., 18, 311 (1968).
Hillman, N. W., and Tasca, R. J., Amer. J. Anat. (in the press).
Perry, R. P., Exp. Cell Res., 29, 400 (1963).
Hillman, N. W., and Tasca, R. J., Proc. Twelfth Intern. Cong. Genetics, Tokyo, Abstr. 7.5.1 (1968).
Jackson, L. G., and Studzinski, G. P., Exp. Cell Res., 52, 408 (1968).
Monesi, V., and Salfi, V., Exp. Cell Res., 46, 632 (1967).
Fautrez-Firlefyn, N., and Fautrez, J., Intern. Rev. Cytol., 22, 171 (1967).
Busch, H., Histones and Other Nuclear Proteins (Academic Press, New York, 1965).
Chalkley, G. R., and Maurer, H. R., Proc. US Nat. Acad. Sci., 54, 498 (1965).
Paul, J., and Gilmour, R. S., J. Mol. Biol., 34, 305 (1968).
Mitchinson, J. M., and Cummins, J. E., J. Cell Sci., 1, 35 (1966).
Pardee, A. B., Nat. Cancer Inst. Monograph., 27, 249 (1967).
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TASCA, R., HILLMAN, N. Effects of Actinomycin D and Cycloheximide on RNA and Protein Synthesis in Cleavage Stage Mouse Embryos. Nature 225, 1022–1025 (1970). https://doi.org/10.1038/2251022a0
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DOI: https://doi.org/10.1038/2251022a0
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