Abstract
WHILE studying a Moloney virus (MV) induced lymphoma in culture, we were puzzled by the disappearance of the antibody-mediated cytotoxic sensitivity of the cells several days after explantation. After a longer time in culture, however, these cells regained sensitivity to the same sera with complement. The experiments have been repeated in better controlled conditions, and some of the results obtained are reported here.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Herzenberg, L. A., and Roosa, R. A., Exp. Cell Res., 21, 430 (1960).
Snell, G. D., and Stimpfling, J. H., in Biology of Laboratory Mouse (edit. by Green, E. L.) (McGraw-Hill, New York, 1966).
Fedoroff, S., In Vitro, 2, 155 (1967).
Paul, J., Cell and Tissue Culture (Williams and Wilkins, Baltimore, 1965).
Klein, E., and Klein, G., J. Nat. Cancer Inst., 32, 547 (1964).
Bagshawe, K. D., and Currie, G. A., Nature, 218, 1254 (1968).
Killander, D., and Zetterberg, A., Exp. Cell Res., 40, 12 (1965).
Nilausen, K., and Green, H., Exp. Cell Res., 40, 166 (1965).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
CIKES, M. Antigenic Expression of a Murine Lymphoma during Growth in vitro. Nature 225, 645–647 (1970). https://doi.org/10.1038/225645a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/225645a0
This article is cited by
-
Comments on the paper by M. T. Zenzes and T. E. Reed hum genet 66:103?109 (1984)
Human Genetics (1984)
-
Antibody mediated complement dependent lysis of virus infected cells
Springer Seminars in Immunopathology (1979)
-
H-2 antigen expression: Loss in vitro, restoration in vivo, and correlation with cell-mediated cytotoxicity in a mouse lymphoma cell line
Immunogenetics (1978)
-
Influence of culture conditions on growth of FL-74 cells and feline oncornavirus cell membrane associated antigen production
In Vitro (1976)
-
Ø-Isoantigenic marker in phytohemagglutinin-responding mouse blood lymphocytes
Experientia (1972)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.