Abstract
VARIOUS explanations have been given for the mechanisms of invasion in cancer1–6. Recently we have isolated a chemotactic factor specific for polymorphonuclear leucocytes (PMNs) from inflamed sites (refs. 7, 8 and M. Yoshinaga, K, Y., A. Tashiro and H. H., manuscript in preparation); it induced marked PMN emigration on experimental injection but did not increase vascular permeability. Similarities in the behaviour of tumour cells and granulocytes in inflammation suggested that a factor chemotactic for tumour cells might exist. We now report the isolation and purification of such a chemotactic substance.
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HAYASHI, H., YOSHIDA, K., OZAKI, T. et al. Chemotactic Factor associated with Invasion of Cancer Cells. Nature 226, 174–175 (1970). https://doi.org/10.1038/226174a0
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DOI: https://doi.org/10.1038/226174a0
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