Abstract
Antibodies directed against soluble components from purified liver lysosomes are taken up by fibroblasts and to impair lysosomal function. As a result, lysosomal hydrolases are inhibited, the uptake and digestion of foreign protein are impaired and there is a marked increase in the size and number of lysosome-like cytoplasmic bodies—resembling the condition seen in many storage diseases.
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TULKENS, P., TROUET, A. & VAN HOOF, F. Immunological Inhibition of Lysosome Function. Nature 228, 1282–1285 (1970). https://doi.org/10.1038/2281282a0
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DOI: https://doi.org/10.1038/2281282a0
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