Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Effects of an Imprinting Procedure on RNA Polymerase Activity in the Chick Brain

Nature volume 228, pages 373–375 (1970)Cite this article

Abstract

EXPOSURE to an imprinting stimulus has been shown to be associated with an increase in incorporation rates of lysine into protein and uracil into RNA in the forebrain roof in one-day-old chicks' brains1,2. A maximum increase in RNA incorporation is seen at 76 min after the start ofthe imprinting procedure and in protein incorporation at 120 min. Studies of the changes occurring in other protein synthesizing systems in response to external stimuli such as hormones have demonstrated a similar type of temporal sequence for the protein and RNA changes. In hormonal systems one of the events preceding both of these is an increase in RNA polymerase activity3. It seemed reasonable to test whether such an effect also occurs during imprinting in the chick. We present here preliminary results of an enquiry into the effects of the imprinting stimulus on the activity of RNA polymerase in three regions of the chick's brain.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Bateson, P. P. G., Horn, G., and Rose, S. P. R., Nature, 223, 534 (1969).

    Article  ADS  CAS  PubMed  Google Scholar 

  2. Rose, S. P. R., Bateson, P. P. G., Horn, A. L. D., and Horn, G., Nature, 225, 650 (1970).

    Article  ADS  CAS  PubMed  Google Scholar 

  3. Tata, J. R., Nature 212, 1312 (1966).

    Article  ADS  CAS  PubMed  Google Scholar 

  4. Bateson, P. P. G., and Reese, E. P., Anim. Behav., 17, 692 (1969).

    Article  Google Scholar 

  5. Mertelsmann, R., Europ. J. Biochem., 9, 311 (1969).

    Article  CAS  PubMed  Google Scholar 

  6. Kato, T., and Kurokawa, M., Biochem. J., 116, 599 (1970).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Burton, K., Biochem. J, 62, 315 (1955).

    Article  Google Scholar 

  8. Rose, S. P. R., FEBS Letters, 5, 305 (1969).

    Article  CAS  PubMed  Google Scholar 

  9. Sarma, P. S., Baron, S., Huebner, R., and Shiu, G., Nature, 224, 604 (1969).

    Article  ADS  CAS  PubMed  Google Scholar 

  10. Sarma, P. S., Shiu, G., Neubauer, B., Baron, S., and Huebner, R. J., Proc. US Nat. Acad. Sci., 62, 1046 (1969).

    Article  ADS  CAS  Google Scholar 

  11. Baron, S., DuBoy, H., Bucker, C. E., Johnson, M. C., Park, J., Billiau, J., Sarma, P. S., and Huebner, R. J., Ann. NY Acad. Sci. (in the press).

  12. Bart, R. S., and Kopf, A. W., Nature, 224, 372 (1969).

    Article  ADS  CAS  Google Scholar 

  13. Jahiel, R. I., Vilock, J., Nussenzweig, R. G., and Vanderberg, J., Science, 161, 802 (1968).

    Article  ADS  CAS  PubMed  Google Scholar 

  14. Shibata, S., Nishikawa, Y., Tanaka, M., Fukuoka, F., and Nakanishi, M., Z. Krebsforsch., 71, 102 (1968).

    Article  CAS  PubMed  Google Scholar 

  15. Deutsch, H. F., J. Biol. Chem., 224, 767 (1957).

    CAS  PubMed  Google Scholar 

  16. Bergsterman, H., Z. Krebsforsch., 60, 644 (1955).

    Article  Google Scholar 

  17. Rich, C., and Meyers, W. P. L., J. Lab. Clin. Med., 54, 223 (1959).

    CAS  Google Scholar 

  18. Ozzello, L., Lasfargeus, E. Y., and Murray, M. R., Cancer Res., 20, 600 (1960).

    CAS  PubMed  Google Scholar 

  19. Takeuchi, J., Nature, 207, 537 (1965).

    Article  ADS  CAS  PubMed  Google Scholar 

  20. Takeuchi, J., Cancer Res., 26, 797 (1966).

    CAS  PubMed  Google Scholar 

  21. Takeuchi, J., Brit. J. Cancer, 20, 847 (1966).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Takeuchi, J., Brit. J. Cancer, 21, 334 (1967).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Takeuchi, J., Gaan, 58, 505 (1967).

    CAS  Google Scholar 

  24. Takeuchi, J., Cancer Res., 28, 1520 (1968).

    CAS  PubMed  Google Scholar 

  25. Brimacombe, J. S., and Webber, J. M., Mucopolysaccharides (Elsevier, Amsterdam, 1964).

    Google Scholar 

  26. Wallach, D. F. H., and Eylar, E. H., Biochim. Biophys. Acta, 52, 594 (1961).

    Article  CAS  PubMed  Google Scholar 

  27. Cook, G. M. W., Heard, D. H., and Seaman, G. V. F., Exp. Cell Res., 28, 27 (1962).

    Article  CAS  PubMed  Google Scholar 

  28. Fuhrmann, G. F., Granzer, E., Kübler, W., Reuff, F., and Ruhenstroth-Bauer, G., Z. Naturforsch., 11B, 610 (1962).

    Article  Google Scholar 

  29. Langley, O. K., and Ambrose, E. J., Biochem. J., 102, 367 (1967).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Mehrishi, J. N., Europ. J. Cancer, 6, 127 (1970).

    Article  CAS  Google Scholar 

  31. Mehrishi, J. N., and Grassetti, D. R., Nature, 224, 563 (1969).

    Article  ADS  CAS  PubMed  Google Scholar 

  32. Mayhew, E., and Weiss, L., Exp. Cell Res., 50, 441 (1968).

    Article  CAS  PubMed  Google Scholar 

  33. Ambrose, E. J., James, A. M., and Lowick, J. H. B., Nature, 177, 576 (1956).

    Article  ADS  PubMed  Google Scholar 

  34. Abercrombie, M., Heaysman, J. E. M., and Karthauser, H. M., Exp. Cell Res., 13, 276 (1957).

    Article  CAS  PubMed  Google Scholar 

  35. Purdom, L., Ambrose, E. J., and Klein, G., Nature, 181, 1586 (1958).

    Article  ADS  CAS  PubMed  Google Scholar 

  36. Ambrose, E. J., Exp. Cell Res. Suppl., 8, 54 (1961).

    Article  Google Scholar 

  37. Abercrombie, M., and Ambrose, E. J., Cancer Res., 22, 525 (1962).

    CAS  PubMed  Google Scholar 

  38. Ambrose, E. J., L'Union Internationale Centre Le Cancer Monog. Series, 6, 130 (1967).

    Google Scholar 

  39. Mehrishi, J. N., Europ. J. Cancer, 5, 427 (1969).

    Article  CAS  Google Scholar 

  40. Mehrishi, J. N., Ann. Rep. Brit. Empire Cancer Campaign, 47, 242 (1969).

    Google Scholar 

  41. Zbinden, G., Mehrishi, J. N., and Tomlin, S., Thrombos. Diathes. Haemor., 23, 261 (1970).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biology, Open University, Walton, Bletchley, Buckinghamshire

    JEFF HAYWOOD & STEVEN P. R. ROSE

  2. Sub-Department of Animal Behaviour, University of Cambridge,

    P. P. G. BATESON

Authors
  1. JEFF HAYWOOD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. STEVEN P. R. ROSE
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. P. G. BATESON
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

HAYWOOD, J., ROSE, S. & BATESON, P. Effects of an Imprinting Procedure on RNA Polymerase Activity in the Chick Brain. Nature 228, 373–375 (1970). https://doi.org/10.1038/228373a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/228373a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing