Abstract
GENETIC hazards from drugs and chemical pollutants are now widely recognized and appropriate, sensitive and economic mammalian methods for detecting and measuring mutagenic effects of chemicals have been developed. These methods are relevant to man1 and include in vivo cytogenetics, host-mediated assay, and dominant lethal assay; sub-mammalian systems are generally considered to be of ancillary value only. The Advisory Panel on Mutagenicity of Pesticides1 and the Food and Drug Administration Advisory Committee on Protocols for Safety Evaluation2 have recommended that pesticides and food additives should be tested for mutagenicity in mammalian systems before registration. This communication recommends practical procedures for the dominant lethal assay, and indicates how these can be integrated in routine toxicological practice.
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EPSTEIN, S., RÖHRBORN, G. Recommended Procedures for testing Genetic Hazards from Chemicals, based on the Induction of Dominant Lethal Mutations in Mammals. Nature 230, 459–460 (1971). https://doi.org/10.1038/230459a0
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DOI: https://doi.org/10.1038/230459a0
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