Abstract
SINCE the first report of hepatic cancer in rats induced by nitrosodimethylamine1, many nitrosamines have been shown to be carcinogenic in a wide range of organs of a wide variety of species1–4. Following the suggestion that dietary nitrite and secondary amines might interact in the human stomach to form nitrosamines5, such synthesis has been demonstrated in vitro with animal and human gastric juice6,7, and in vivo in laboratory animals7 and man8; nitrosamine synthesis was pH-dependent7–10. Nitrosamines can also be synthesized in vitro at near neutral pH values in the presence of enteric bacteria11; yields of nitrosamines are also determined by the basicity of the secondary amine. Presumptive evidence for in vivo synthesis of nitrosamines has been demonstrated by the induction of tumours in rats following chronic feeding of nitrite and secondary amines11. We report here the synthesis of nitrosopiperidine in rats from nitrite and piperidine in gastric contents in vitro, and in the stomach and in the small intestine in vivo.
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ALAM, B., SAPOROSCHETZ, I. & EPSTEIN, S. Formation of N-Nitrosopiperidine from Piperidine and Sodium Nitrite in the Stomach and the Isolated Intestinal Loop of the Rat. Nature 232, 116–118 (1971). https://doi.org/10.1038/232116a0
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DOI: https://doi.org/10.1038/232116a0
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