Abstract
Viral RNA can be detected in L cells pretreated with interferon and infected with vaccinia virus, but protein synthesis ceases as early as 20 min after infection. The effect of interferon must therefore be at the stage of translation rather than transcription.
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References
Colby, C., and Morgan, M. J., Ann. Rev. Microbiol., 25, 333 (1971).
Joklik, W. K., and Merigan, T. C., Proc. US Nat. Acad. Sci., 56, 558 (1966).
Levy, H. B., and Carter, W. A., J. Mol. Biol., 31, 561 (1968).
Friedman, R. M., J. Virol., 2, 1081 (1968).
Kerr, I. M., J. Virol., 7, 448 (1971).
Marcus, P. I., Engelhardt, D. L., Hunt, J. M., and Sekellick, M. J., Science, 174, 593 (1971).
Bialy, H. S., and Colby, C., J. Virol., 9, 286 (1972).
Oxman, M. N., and Levin, M. J., Proc. US Nat. Acad. Sci., 68, 299 (1971).
McAuslan, B. R., in The Biochemistry of Viruses (edit. by Levy, H. B.) (Dekker, New York and London, 1969).
Woodson, B., Biochem. Biophys. Res. Commun., 27, 169 (1967).
Moss, B., J. Virol., 2, 1028 (1968).
Kates, J. R., and McAuslan, B. R., Proc. US Nat. Acad. Sci., 57, 314 (1967).
Paucker, K., Berman, B. J., Golgher, R. R., and Stancek, D., J. Virol., 5, 145 (1970).
Stewart, W. E., Gosser, L. B., and Lockart, R. Z., J. Virol., 7, 792 (1971).
Nazer, R. N., Lawford, H. G., and Wong, J. T. F., Anal. Biochem., 35, 305 (1970).
Kates, J., and Beeson, J., J. Mol. Biol., 50, 1 (1970).
Oda, K. I., and Joklik, W. K., J. Mol. Biol., 27, 395 (1967).
Horak, I., Jungwirth, C., and Bodo, G., Virology, 45, 456 (1971).
Jungwirth, C., Horak, I., Bodo, G., Lindner, J., and Schultze, B., Virology, 48, 59 (1972).
Joklik, W. K., Biochim. Biophys. Acta, 61, 290 (1962).
Becker, Y., and Joklik, W. K., Proc. US Nat. Acad. Sci., 51, 577 (1964).
Russell, W. C., and Skehel, J. J., J. Gen. Virol., 15, 45 (1972).
Friedman, R. M., Esteban, R. M., Metz, D. H., Tovell, D. R., Kerr, I. M., and Williamson, R., FEBS Lett. (in the press).
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METZ, D., ESTEBAN, M. Interferon inhibits Viral Protein Synthesis in L Cells infected with Vaccinia Virus. Nature 238, 385–388 (1972). https://doi.org/10.1038/238385a0
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DOI: https://doi.org/10.1038/238385a0
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