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Evidence that mitogenic lectins induce changes in lymphocyte membrane fluidity

Nature volume 249, pages 465–466 (1974)Cite this article

A Corrigendum to this article was published on 15 May 1975

Abstract

MITOGENIC plant lectins, such as phytohaemagglutinin (PHA) and concanavalin A (con A), are useful tools to study the control of cell proliferation in lymphocytes. Recent evidence suggests that these mitogenic lectins trigger mitogenesis at the cell membrane1,2. It is likely that an understanding of the mechanisms by which these lectins stimulate lymphocytes will provide important clues to more general problems of the regulation of proliferation in eukaryotic cells.

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Authors and Affiliations

  1. Departments of Chemistry and Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, 55455

    RONALD E. BARNETT, ROBERT E. SCOTT, LEO T. FURCHT & JOHN H. KERSEY

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  1. RONALD E. BARNETT
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  2. ROBERT E. SCOTT
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  3. LEO T. FURCHT
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  4. JOHN H. KERSEY
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BARNETT, R., SCOTT, R., FURCHT, L. et al. Evidence that mitogenic lectins induce changes in lymphocyte membrane fluidity. Nature 249, 465–466 (1974). https://doi.org/10.1038/249465a0

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