Abstract
THREE distinct states of the rat uterus with respect to ovoimplantation have been described. The prereceptive stage lasting from day 1 to day 4 is followed by receptivity during day 5; finally, during a postreceptive period from day 6 onwards, transferred mature blastocysts do not implant if implantation on day 5 has been prevented1. Analogous situations can be created in the castrated animal by treatment with a precise sequence of hormones; a minimum of 2 d of progesterone preparation is necessary to obtain, 18 h after the subsequent administration of a small dose of oestrogen the state of receptivity for ovoimplantation which will last for approximately 12 h. Again, a period during which the fertilised egg cannot implant will follow the time of receptivity, as shown by egg transfer experiments1.
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MESTER, I., MARTEL, D., PSYCHOYOS, A. et al. Hormonal control of oestrogen receptor in uterus and receptivity for ovoimplantation in the rat. Nature 250, 776–778 (1974). https://doi.org/10.1038/250776a0
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DOI: https://doi.org/10.1038/250776a0
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