Abstract
MODULATION of cellular function by the autonomic nervous system is accomplished, at least in part, by the stimulation of β-adrenergic receptors by catecholamines at neuroeffector junctions1. Activation of these receptors results in stimulation of adenylate cyclase with increased intracellular levels of cyclic AMP. The β-adrenergic receptors of a variety of non-neural tissues have been characterised indirectly by measurement of altered adenylate cyclase activity or of intracellular cyclic AMP in response to β-adrenergic agonists and antagonists. Direct characterisation of the β-adrenergic receptors in avian2,3 and amphibian4 erythrocytes and in canine heart5 has been accomplished by binding assays using radioactive β-adrenergic antagonists.
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ALEXANDER, R., DAVIS, J. & LEFKOWITZ, R. Direct identification and characterisation of β-adrenergic receptors in rat brain. Nature 258, 437–440 (1975). https://doi.org/10.1038/258437a0
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DOI: https://doi.org/10.1038/258437a0
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