Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Review Article
  • Published:

Quantitative variation and gene number

Abstract

Gene number estimates from fine structure analysis seem to be incompatible with the number of genes often presumed to affect quantitative characters. This paradox can be resolved by reconsidering the available evidence about the nature of polygenes.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Judd, B. H., Shen, M. W., and Kaufman, T. C., Genetics, 71, 139–156 (1972).

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Hochman, B., Cold Spring Harb. Symp. quant. Biol., 38, 581–589 (1973).

    Article  Google Scholar 

  3. Judd, B. H., and Young, M. W., Cold Spring Harb. Symp. quant. Biol., 38, 573–579 (1973).

    Article  Google Scholar 

  4. O'Brien, S. J., Nature new Biol., 242, 52–54 (1973).

    Article  CAS  PubMed  Google Scholar 

  5. Lewin, B., Nature, 251, 373–375 (1974).

    Article  ADS  Google Scholar 

  6. Britten, R. J., and Davidson, E. H., Science, 165, 349–357 (1969).

    Article  ADS  CAS  PubMed  Google Scholar 

  7. Crick, F., Nature, 234, 25–27 (1971).

    Article  ADS  CAS  PubMed  Google Scholar 

  8. Mather, K., Biometrical Genetics (Methuen, London, 1949).

    Google Scholar 

  9. Thoday, J. M., Nature, 191, 368–370 (1961).

    Article  ADS  Google Scholar 

  10. Gibson, J. B., and Thoday, J. M., Heredity, 17, 1–26 (1962).

    Article  CAS  PubMed  Google Scholar 

  11. Wolstenholme, D. R., and Thoday, J. M., Heredity, 18, 413–431 (1963).

    Article  CAS  PubMed  Google Scholar 

  12. Thoday, J. M., Gibson, J. B., and Spickett, S. G., Genet. Res., 5, 1–19 (1964).

    Article  Google Scholar 

  13. Spickett, S. G., and Thoday, J. M., Genet. Res., 7, 96–121 (1966).

    Article  CAS  PubMed  Google Scholar 

  14. Falconer, D. S., Introduction to Quantitative Genetics (Oliver and Boyd, London, 1960), from the data of Clayton, G. A., and Robertson, A., J. Genet., 55, 152–170 (1955).

    Google Scholar 

  15. Milkman, R. D., Genetics, 65, 289–303 (1970).

    CAS  PubMed  PubMed Central  Google Scholar 

  16. Boyer, B. J., Parris, D. L., and Milkman, R., Genetics, 75, 169–179 (1973).

    CAS  PubMed  PubMed Central  Google Scholar 

  17. Pandey, K. K., Theor. appl. Genet., 42, 250–261 (1972).

    Article  CAS  PubMed  Google Scholar 

  18. Scharloo, W., Nature, 203, 1095–1096 (1964).

    Article  ADS  CAS  PubMed  Google Scholar 

  19. Rendel, J. M., Canalisation and Gene Control (Logos, London, 1967).

    Google Scholar 

  20. Fraser, A., Genetics, 57, 919–934 (1967).

    CAS  PubMed  PubMed Central  Google Scholar 

  21. Thompson, J. N., JR, Genet. Res., 22, 211–215 (1973).

    Article  PubMed  Google Scholar 

  22. Thompson, J. N., JR, Heredity, 33, 373–387 (1974).

    Article  PubMed  Google Scholar 

  23. Thompson, J. N., JR, Genetics, 81, 387–402 (1975).

    PubMed Central  Google Scholar 

  24. Lindsley, D. L., and Grell, E. H., Genetic Variations of Drosophila melanogaster (Carnegie Institution of Washington Publ. No. 627, 1967).

    Google Scholar 

  25. Spickett, S. G., Nature, 199, 870–873 (1963).

    Article  ADS  CAS  PubMed  Google Scholar 

  26. Jacobson, C., thesis, Sidney Univ.; quoted in Fraser, A., Genetics, 57, 919–934 (1967).

    Google Scholar 

  27. Thompson, J. N., JR, and Thoday, J. M., Heredity, 33, 430–437 (1974).

    Article  PubMed  Google Scholar 

  28. Scharloo, W., Genetics, 65, 681–691 (1970).

    CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Thompson, J. Quantitative variation and gene number. Nature 258, 665–668 (1975). https://doi.org/10.1038/258665a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/258665a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing