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Models for metal ion function in carbonic anhydrase

Abstract

A model catalyst is described which has properties in common with carbonic anhydrase. The model demonstrates the availability of a mechanism, previously only hypothetical, for the action of the enzyme. It also shows, however, that this mechanism alone is not adequate to produce the high activity of the enzyme.

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Woolley, P. Models for metal ion function in carbonic anhydrase. Nature 258, 677–682 (1975). https://doi.org/10.1038/258677a0

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